Arsenal players have sustained 889 injuries since August 2002, according to a report by PhysioRoom.com.
The Gunners' 889 injuries over the 12-year period compare to 792 for Manchester United, 620 for Chelsea and 551 for Liverpool.
Arsene Wenger's side is currently suffering from its latest injury crisis after Aaron Ramsey and Mikel Arteta joined long-term absentees Olivier Giroud and Mathieu Debuchy on the sidelines.
Ramsey is set for a month out after picking up a hamstring injury in Saturday's 1-1 draw with Tottenham while Arteta suffered a calf problem.
Abou Diaby, who has recently returned to fitness, has endured 40 separate injuries, according to the study, while Theo Walcott, who is currently recovering from a serious knee problem, features 42 times.
Other regular names on the injury list are Tomas Rosicky with 36 and Kieran Gibbs with 27 fitness problems.
PhysioRoom.com claims 120 of the injuries were of the hamstring variety while six anterior cruciate ligament (ACL) have been suffered.
This week, Wenger admitted he does not understand why his club are suddenly in the midst of an injury crisis.
Arsenal are next in action on Wednesday night in the Champions League against Galatasaray, having lost their opening Group D game to Borussia Dortmund.