Suarez, 34 -- who was allowed to leave Barca to join Atletico last summer -- has 19 league goals this season but hasn't found the net since March 21.
"We're entering the Suarez zone," Simeone said in a news conference on Saturday. "It's the ideal moment for a player like him to find and resolve the situations that the team will need him to. He's used to these kinds of games, and he has the experience to do it."
"We'll keep doing what we always do," Simeone said, when asked about that high-pressure situation. "We'll try to win our match, that's most important. The team looks hopeful and enthusiastic to me."
Suarez has said that the manner of his Barcelona departure -- when he was deemed surplus to requirements at Camp Nou by coach Ronald Koeman -- left him desperate to prove a point.
His form peaked in January and February, scoring seven goals in four games, but he has struggled since then, coinciding with the team's worsening form.
Atletico have led the La Liga table since December -- enjoying a 10-point lead over their title-chasing rivals in January -- but a new-year wobble has seen them lose three games and draw six more since then.
"Every team has difficulties during the season," Simeone said. "The coach has to look for solutions. The team has improved, we had good second halves [in the defeats against] Sevilla and Athletic. We're played well in the last few games."
A goalless draw with Barcelona last Saturday looked to have handed the initiative to Real Madrid, before they were also held to a draw by Sevilla the following day.