Ousmane Dembele, Samuel Umtiti and Gavi all tested positive for the virus on Wednesday to take the number of players isolating at the club to seven. Jordi Alba, Clement Lenglet, Dani Alves and Alejandro Balde had all tested positive earlier this week.
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Barca have said all seven players feel fine and are quarantining at home in line with the league's protocol.
The outbreak leaves Barca extremely short heading into this weekend's game against Mallorca, their first match since a 1-1 draw with Sevilla on Dec. 21.
Sergio Busquets is suspended for the trip to San Moix on Sunday, as is Gavi, who has now tested positive for coronavirus.
Barca also have a lengthy injury list, with Dest, Sergi Roberto, Memphis Depay, Martin Braithwaite, Ansu Fati and Pedri all absent for their last game. Dest, Pedri and Ansu are all nearing a return to action, though.
Mallorca have said that they have detected four cases among their first-team squad and three more among coaching staff ahead of Barca's visit.
The Omicron variant of the virus has seen cases spiral in the Spanish top-flight.
LaLiga has been on a short winter break since Real's last match on Dec. 22 and the pacesetters are back in action on Jan. 2 when they travel to Getafe in LaLiga.
Real Sociedad are among the other clubs hardest hit by the latest wave. They announced 10 cases within their first-team bubble on Dec. 27.
A LaLiga spokesman told ESPN there was "no news" regarding possible postponements this weekend, but the league have made their stance on games going ahead clear in the past.
Granada were forced to play a game against Sociedad last season after an outbreak. They ended the fixture with just four members of their senior squad on the pitch.
The Spanish Football Federation (RFEF) and league organisers had rejected Granada's request to postpone the game because they were able to field seven players from their first-team squad from the start. Rules state that matches can only be postponed if five or fewer first-team players are available.
Information from Reuters was also included in this report.