Michael Ibe's goal for 10-man Akwa United sealed a 1-0 away victory against Yobe Desert Stars on a weekend in which league leaders Lobi Stars lost.
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The title-favourites in the Nigeria Professional Football League failed to show the stuff of champions on match-day 14.
Enyimba denied Kano Pillars top spot in the Nigeria Professional Football League following a 1-1 draw.
Title favourites Akwa United, Plateau United and Kano Pillars maintained their early season lead by scoring a combined 11 goals in a frantic match-day
Plateau United failed to capitalise on MFM's slip up, while Enugu Rangers made it three wins on the trot.
League leaders Plateau United suffered a shock defeat on a day when all 10 home teams walked away with three points.
Akwa United's title challenge faces a stern test on Wednesday when they travel to Port Harcourt for a rescheduled NPFL fixture against Rivers United.
Plateau United maintained their five-point lead at the top of the standings, while Akwa United kept the pressure on the league leaders.
Rivers United, Nigeria's last representatives in CAF competition, were eliminated from the Confederation Cup after a 2-1 defeat by FUS Rabat.
Tady Etekiama scored twice in the first half to set up AS Vita Club for their first victory of the African Champions League group phase, resurrecting
Nigeria league leaders Plateau United were the big winners on match-day 21, while champions Enugu Rangers suffered another heavy defeat.
Midweek games return on Wednesday in the NPFL, and based on fixtures and form, fans shouldn't expect radical changes at the top of the standings.
Emeka Atuloma scored a winner 18 minutes from time as Rivers United defeated FUS Rabat in their CAF Confederation Cup clash on Wednesday.
Holders TP Mazembe Englebert of DR Congo got off to a winning start on the opening weekend of the expanded group phase of the CAF Confederation Cup.
Only one Nigerian club - Rivers United - is still in the running for continental glory this season.
Rangers and Rivers United won their respective rescheduled Nigeria Professional Football League games played on Wednesday.
Sunshine Stars received a huge boost in a debut win under new manager Austin Eguavoen while Rangers's defeat drops the champions to 19th in the table.
African Champs Sundowns will get a chance to make a point about last year's good fortune in the Champions League following the group stage draw.
Rangers have suffered quite enough this season. But if their 3-1 win over Kano Pillars is anything to go by, it appears their woes are almost over.
Nigerian side Rivers United have taken the final spot on the CAF Confederations Cup group stages after a 2-0 aggregate win against Rayon Sports.
It won't be long before NPFL followers run out of adjectives to describe 19-year-old striker Stephen Odey following his brace against leaders Plateau.
El Kanemi win 20th straight at home, Akwa United continue to rise up the table after disastrous start headline Nigerian Premier League Matchday 13.