Hosts Brazil have been drawn to face Peru, Venezuela and Bolivia in the 2019 Copa America that kicks off in Sao Paulo in June.
Thursday's draw also placed seeded Argentina with Colombia, Paraguay and invited guests Qatar.
The third of the three top seeds Uruguay face the other invited guests Japan, plus Ecuador and reigning champions Chile.
This year's tournament will kick off with Brazil against Bolivia in Sao Paulo on June 14 and take place in five Brazilian cities. The final is at Rio de Janeiro's Maracana stadium on July 7.
"People have questioned me about the draw and some said, it's easy, others said, be careful," Brazil coach Tite said. "Our responsibility is to perform at the highest level, to play with joy and to be proud of representing Brazil."
"We need to play really well, and that's how you become champions."
Incoming federation boss Rogerio Caboclo told Reuters that Tite's future "doesn't depend" on success for Brazil.
"There's no link between the two things. His contract is for four years and is to be served for four years. Even if we're not champions."
The draw at a cavernous Rio concert hall was led by former Brazil captain Cafu and aided by soccer luminaries like former Inter Milan defender Javier Zanetti, Uruguayan Diego Lugano and six times FIFA Player of the year Marta.
It marked the starting gun for what promises to be a high pressure year for both Brazil and Argentina.
The host nation have not won a major title since lifting the Copa America in 2007 and coach Tite, whose side were knocked out the World Cup at the quarterfinal stage last year, is under pressure to deliver some silverware.
Tite said he is hopeful Paris Saint-Germain star Neymar -- who suffered a right injury earlier this week -- would be available, while leaving the door open for Real Madrid emerging youngster Vinicius Jr. to be part of O Selecao.
Argentina, meanwhile, have reached the last two finals of the Copa America and lost both times on penalties to Chile. Another loss would extend a trophy drought that stretches back to 1993.
The two-times World Cup winners will come to the tournament with Lionel Scaloni in charge and although the interim coach, who has a contract until after the Copa, would not be drawn on his rivals he said his aim was to triumph.
"It's going to be difficult and no matter who we play we have to win," he told reporters. "The idea is that we are as good as anyone; we just need to keep notching up the victories."
They could also be without Lionel Messi. The Barcelona forward took a sabbatical from international soccer after a disappointing World Cup in Russia and has not said whether he will return to play in Brazil.
The Copa America is the oldest international tournament in the world and is played between the 10 South American nations and invited teams.
In addition to Rio de Janeiro and Sao Paulo, matches will be held in Porto Alegre, Belo Horizonte and Salvador.
"Undoubtedly, there is always a great respect and admiration for Brazil's footballing culture," said Chilean coach Reinaldo Rueda.
"I think that will guarantee a great tournament."