The season, which started in October, had only reached the halfway stage and was due to be completed in June.
"We don't know when this pandemic will go away. With the approach of the rainy season and the presence of the pandemic, we have decided that we have to stop the championship," Mathurin Bangoura, president of the Guinean Professional Football League, said.
No champions will be crowned but the top four in the standings at the time of the league's suspension will compete in next season's continental competitions -- the CAF Champions League and the Confederation Cup. There will also be no promotion or relegation.
Mauritius became the first African country to call a halt to its season because of the coronavirus outbreak. Kenya and Angola followed, but clubs in Madagascar voted to attempt to carry on after a meeting on Thursday.
The Confederation of African Football has told member associations to set a May 5 deadline to reveal whether they intend to continue with their domestic programs or call an end to their respective seasons.