Suso spared AC Milan from the prospect of a frustrating home draw with Cagliari by whipping in a match-winning free kick at San Siro.
The ambitious Rossoneri led their Sardinian opponents in the 10th minute when teenager Patrick Cutrone grabbed his second goal in as many games, but Cagliari soon capitalised on a Franck Kessie mistake to level through Joao Pedro.
In the 70th minute, former Liverpool winger Suso steered a perfect set-piece beyond Alessio Cragno for a 2-1 victory.
Fellow Serie A title hopefuls Napoli won 3-1 for the second time this season as Piotr Zielinski's thunderbolt launched a successful comeback against Atalanta.
Bryan Cristante's fourth-minute opener gave Napoli food for thought and it was not until the 56th minute that Zielinski conjured up a half-volleyed drive from distance that rippled the top of the net.
Dries Mertens and Marko Rog then put the game beyond Atalanta with their first goals of the new campaign.
Andrea Belotti kept himself in the shop window ahead of Thursday's transfer deadline by scoring an acrobatic opener in Torino's 3-0 home victory over Sassuolo.
The Italy striker, who scored 26 league goals for Il Toro last term, is a reported target of Chelsea and Monaco but his €100 million asking price is a sticking point for potential suitors.
He reminded any scouts in attendance at the Stadio Olimpico on Sunday of his ability with a scissor-kick that powered Lorenzo De Silvestri's cross home for a 45th-minute opener and Torino wrapped up the three points with late goals from Adem Ljajic and Joel Obi.
Luca Rizzo wrote his name into SPAL's history books by clinching the Ferrara club's first top-flight victory in almost 50 years.
The second-tier champions led Udinese through summer signing Marco Borriello and Manuel Lazzari -- the latter being awarded a goal thanks to VAR -- but the Zebrette bit back with Bram Nuytinck notching before Cyril Thereau slotted in a controversial late spot-kick.
Step forward Rizzo in the fourth minute of stoppage time. The Bologna loanee danced his way into the box before picking out the bottom corner to make it 3-2 to SPAL.
Sergej Milinkovic-Savic's late rocket fired Lazio to a nervous 2-1 victory at Chievo.
Ciro Immobile opened the scoring but Manuel Pucciarelli promptly equalised for Chievo, who were chasing back-to-back wins. They would be denied as, with a minute remaining, Milinkovic-Savic produced his stunning winner.
Sampdoria had veteran striker Fabio Quagliarella to thank in their 2-1 triumph at Fiorentina, who have now lost their two opening fixtures.
Gianluca Caprari converted his own saved shot to give Samp the lead in Florence after the half-hour mark, with 34-year-old Quagliarella then converting a penalty to negate the effect of Milan Badelj's second-half response for the hosts.
Elsewhere, Hellas Verona ground out a goalless draw at Crotone to pick up their first point since winning promotion.
Crotone enjoyed the best chance to snatch all three points as Arlind Ajeti hit the crossbar with six minutes remaining.