Juventus midfielder Sami Khedira is set to spend two months on the sidelines after sustaining a thigh injury.
Khedira, who joined the club from Real Madrid this summer, sustained the injury while chasing the ball during the 2-0 friendly defeat to Marseille at the weekend.
A statement on Juve's official website read: "Sami Khedira will be sidelined for approximately two months after medical examinations revealed a second-grade myotendinous tear of the rectus femoris muscle in his right thigh.
"The German midfielder sustained the injury during last Saturday's preseason friendly against Olympique Marseille at the Stade Velodrome."
- JuventusFC (@juventusfcen) August 3, 2015
It was the 28-year-old's first appearance in a Bianconeri shirt after missing the friendly against Borussia Dortmund due to a muscular problem.
Khedira managed only 628 minutes for Real last season due in part to a succession of minor knocks and sprains.
He also missed the World Cup final due to a muscular injury he picked up during the warmup, while a knee ligament injury in 2013 kept him out of action for almost six months.
Juventus set off for Shanghai on Sunday with worries growing ahead of Saturday's Italian Supercoppa against Lazio in Shanghai.
Juve, who allowed Andrea Pirlo and Arturo Vidal to leave this summer, have now seen their midfield options further reduced by Khedira's injury, and they also have problems in defence after Giorgio Chiellini suffered a thigh injury last week.
Martin Caceres partnered Leonardo Bonucci in the centre of a back four against Marseille, but Andrea Barzagli, who missed that game after picking up an injury against Dortmund, may recover in time to face Lazio.
The Serie A season starts on Aug. 23 with Juve hosting Udinese, while they will play their first Champions League fixture on Sept. 15 or 16.