Tottenham have been drawn to face West Ham in the Carabao Cup quarterfinal with Brentford taking on Chelsea in another all-London derby.
Lucas Moura headed the winner as Tottenham Hotspur beat Burnley 1-0 to book their place in the Carabao Cup quarterfinals.
It had been five years and one day since Man City last lost a Carabao Cup match. West Ham ended that streak on Wednesday with a gritty shootout win.
Holders Manchester City have been eliminated from the Carabao Cup by West Ham United after a penalty shootout at the London Stadium on Wednesday.
Liverpool advanced to the Carabao Cup quarterfinals on a fine showing by Adrian in the net that led Jurgen Klopp's side past Preston North End.
Takumi Minamino and Divock Origi and each scored to give Liverpool a win over Preston North End and advance to the quarterfinals of the Carabao Cup.
Arsenal's win over Leeds to reach the Carabao Cup quarterfinals has further squad implications beyond the chance to win silverware for Mikel Arteta.
Arsenal moved into the Carabao Cup quarterfinals with a 2-0 victory over fellow Premier League side Leeds United.
Chelsea beat Southampton in a shootout in the fourth round of the Carabao Cup at Stamford Bridge on Tuesday after the game ended in a 1-1 draw.
Man United made 11 changes for their Carabao Cup tie vs. West Ham, but the Red Devils would miss the production of their regulars in a sorry defeat.
Tottenham Hotspur surrendered an early 2-0 lead at Wolverhampton Wanderers but eventually won 3-2 on penalties in the Carabao Cup.
Man City will face West Ham in the fourth round of the Carabao Cup, while Arsenal welcome Leeds United.
A much-changed Chelsea side crept into the fourth round of the League Cup as they beat Aston Villa 4-3 on penalties.
Arsenal beat third-tier AFC Wimbledon in the Carabao Cup on Wednesday night, with Alexandre Lacazette scoring once and setting up the second.
Manchester United have been knocked out in the third round of Carabao Cup after a 1-0 defeat to West Ham United at Old Trafford on Wednesday.