Liverpool striker Christian Benteke is one of a number of big names manager Brendan Rodgers is resting for their Europa League opener in Bordeaux, according to the Press Association and Liverpool Echo.
Benteke, a £32.5 million summer signing from Aston Villa, has reportedly been left behind on Merseyside along with fellow new arrivals James Milner and Nathaniel Clyne, plus first-choice centre-backs Martin Skrtel and Dejan Lovren and midfielder Lucas Leiva.
That means Mamadou Sakho is set for his first appearance of the season alongside Kolo Toure in what is likely to be a much-changed back four.
Up front, Belgium striker Divock Origi is in line for the first start of his Liverpool career while midfielder Adam Lallana has returned to fitness and is also in contention.
Captain Jordan Henderson will also be absent after undergoing a specialist procedure in the United States in an attempt to cure an ongoing heel problem.
Despite Rodgers resting many of his key stars for the competition, Liverpool first-team coach Gary McAllister says they are keen to succeed in the Europa League.
McAllister, 50, was part of the Liverpool side that beat Alaves 5-4 to win the 2001 UEFA Cup final and the Scot told the club's official website that they are keen to continue their legacy of European success.
"Having experienced it as the UEFA Cup, it's very important as far I'm concerned," he said. "It brought me some wonderful memories and it was a fantastic final against Alaves so, for me, my take on it is that we want to go as far as we possibly can.
"It's a long run, it's a lot of games, I'm not so sure if I'm a fan of the structure of the Europa League, but once you get to the nitty gritty of the last eight it's obviously a competition worth winning and Liverpool have got a history of winning it.
"My generation of player, I associate Liverpool with success in Europe, whether it be in the old UEFA Cup, the old European Cup or Champions League and Europa League.
"So I'm sure it's something the manager and everybody here, all of the players, want to do well in."