Kaka limped out of Orlando City SC's MLS season opener against New York City FC with hamstring injury.
The 2007 World Player of the Year lasted just 11 minutes on Sunday before asking coach Jason Kreis to be substituted.
Giles Barnes replaced the former AC Milan and Real Madrid star.
The match marks the club's first in their new Orlando City Stadium.
Kaka, a World Cup winner with Brazil in 2002, scored nine goals and provided a further 10 assists with Orlando last season.