Eugenio Corini resigned as Palermo coach on Tuesday after guiding the Sicilian club to only one win in seven matches. The move came two days after Palermo were beaten 1-0 at home by Inter Milan.
"This is a decision that I've taken with integrity and lucidness, which makes me feel great pain, but which seems the fairest and most logical option right now," Corini said, according to the ANSA news agency.
Corini was hired in November as Palermo's third coach of the season.
Davide Ballardini coached the club for the opening two rounds then was replaced by Roberto De Zerbi, who was fired to make room for Corini.
With only two wins in 21 matches, Palermo are one point above last-place Pescara in Serie A.
Palermo president Maurizio Zamparini has made about 60 coaching changes in 30 years as a club owner. Last season alone, Zamparini changed coach eight times.
No immediate replacement was named, although there were reports that Zamparini was considering rehiring Ballardini.