Portugal are going to the Confederations Cup without Eder, their goal-scoring hero in the final of the European Championship, and rising star Renato Sanches.
Coach Fernando Santos left the pair off his 24-man squad on Thursday for a friendly against Cyprus, a World Cup qualifier against Latvia, and the Confederations Cup in Russia next month.
Eder and Sanches were the conspicuous absences in the squad that will be led by Cristiano Ronaldo.
A year ago, Eder, a substitute, scored in extra time to give his team a 1-0 win over France and the European title.
Young midfielder Sanches was talked about at that tournament as a possible heir to Ronaldo and subsequently earned a high-profile transfer from Benfica to Bayern Munich, where he hasn't featured regularly. Sanches was instead included in the Portugal under-21s.
Portugal host Cyprus on June 3 and play at Latvia in a World Cup qualifier on June 9.
Four days later, Portugal travel to Russia where they plays their first Confederations Cup game against Mexico on June 18. The Portuguese will also meet Russia and New Zealand in the group stage.
The full squad:
Goalkeepers: Rui Patricio (Sporting Lisbon), Beto (Sporting), Jose Sa (FC Porto)
Defenders: Bruno Alves (Cagliari), Cedric Soares (Southampton), Eliseu (Benfica), Nelson Semedo (Benfica), Jose Fonte (West Ham), Luis Neto (Zenit St. Petersburg), Pepe (Real Madrid), Raphael Guerreiro (Borussia Dortmund)
Midfielders: Adrien Silva (Sporting), Andre Gomes (Barcelona), Danilo Pereira (FC Porto), Joao Mario (Inter Milan), Joao Moutinho (Monaco), Pizzi (Benfica), William Carvalho (Sporting Lisbon)
Forwards: Andre Silva (FC Porto), Bernardo Silva (Monaco), Cristiano Ronaldo (Real Madrid), Gelson Martins (Sporting Lisbon), Ricardo Quaresma (Besiktas), Nani (Valencia)