Manchester City striker Jesus opened the scoring after six minutes with a header and Thiago Silva made it two seven minutes later.
Philippe Coutinho got the third goal from the penalty spot after 37 minutes and was unlucky not to add to his personal total when he saw two other shots come back off the woodwork.
Jesus got a fourth two minutes after the break and Neres, in his first start for the national side, made it 5-0 with a cheeky shot in the 56th minute.
"We played well in the last two friendlies," Jesus said. "We imposed our game and our style of play. I think you gain confidence from that and the confidence we gained means we can keep doing what we've been doing."
The win was the perfect run-out for the host nation before they begin their Copa America campaign against Bolivia in Sao Paulo on June 14.
Brazil, who have not won the Copa America since 2007, are in Group A with Bolivia, Peru and Venezuela.
Honduras now travel to Jamaica, where they face the host nation in the Gold Cup. The Central Americans are in Group C along with Jamaica, Curacao and El Salvador.