Scotland manager Gordon Strachan has left his post after the nation's failure to qualify for the 2018 World Cup.
Scotland missed out on a place in the playoffs when their dramatic 2-2 draw in Slovenia on Sunday, combined with a win for Slovakia, meant the latter clinched runners-up spot in Group F.
The Scottish FA said it would discuss the former Coventry, Southampton,. Celtic and Middlesbrough manager's position at a board meeting on Thursday.
And following those talks, the organisation released a statement that said: "The board of the Scottish FA and Gordon Strachan have agreed that the Scotland national team will be led by a new head coach in preparation for the Euro 2020 qualifying campaign.
"Gordon's tenure will end with immediate effect along with that of his assistant coach, Mark McGhee. We are grateful to Gordon for the passion, professionalism and commitment demonstrated since his appointment in January 2013."
Stewart Regan, the Scottish FA chief executive, said: "I know how disappointed he was that we couldn't secure a playoff place, but to come so close was a tribute to the belief he instilled in his squad.
"After almost five years, the board felt it was time for a new direction to prepare for the Euro 2020 qualifying campaign and also the forthcoming UEFA Nations League."
Strachan said becoming Scotland manager had been "the proudest moment of my career" and added: "I would like to thank each and every player who has come in to represent their country.
"Together we have shared some really magical moments, and those memories will live with me for ever.
"Of course, what made those moments special was the unwavering support of our fans.
"Through highs and lows you have stayed with the team, and my biggest regret is not being able to provide the finals tournament you deserve."
After the Slovenia match, Strachan bemoaned Scotland's genetic make-up, saying their players were smaller than most opposition teams.