Vincenzo Montella is hoping it is fourth time lucky as Sevilla attempt to overcome Manchester United and reach the Champions League quarterfinals.
The La Liga side have failed in their three previous attempts to progress from the competition's last-16, including falling at this stage against Leicester last season.
Sevilla's only dalliance with the European Cup quarterfinals came in 1958 and Montella is hoping to make history at Old Trafford, having put in a promising display as the first leg ended 0-0.
"It is a big opportunity for us,'' said the Italian, who will be without former Manchester City wide man Jesus Navas through injury.
"We'll be playing 100 percent to try and achieve that.
"We know it's a tough task and we're going to suffer throughout the 90 minutes or longer.
"It's a very special game tomorrow night for Seville. It is a very important game for us.
"To keep going and try to get through to the quarterfinal would be great for us.
"It's a big comp, it would be the first time in 60 years for us to get through to this stage.
"We know we've got to score first and foremost to get through, but we have a lot of confidence in our ability.
"We know it's going to be tough, it's a very competitive even-stevens game.''