Harry Kane has told Tottenham he wants to leave the club this summer, sources have told ESPN.
Sources said the England captain expressed his desire to move on during a face-to-face meeting with chairman Daniel Levy, and he would prefer to remain in the Premier League.
Manchester United, Manchester City and Chelsea have all lodged interest with Kane's representatives, but it remains to be seen whether any club will offer the £150 million it will likely take to convince Spurs to sell.
Kane, 27, had repeatedly dropped hints about his frustration over a lack of silverware despite becoming one of the Premier League's most prolific strikers, scoring 165 goals in 243 appearances to sit seventh on the all-time list.
However, he has yet to win a trophy with Tottenham or England. The club's most recent setback came last month when Spurs lost the Carabao Cup final to City 1-0 at Wembley.
Head coach Jose Mourinho was sacked six days before that game after a disappointing campaign in which they will miss out on Champions League qualification barring a mathematical miracle in the final week.
Despite this, Kane's individual performances have remained strong. With 22 goals and 13 assists, only Bayern Munich's Robert Lewandowski (40) and Lionel Messi (39) have more goal involvements in Europe's top five leagues in this season.
Kane has not handed in a transfer request and, significantly, he has three years remaining on his £200,000-a-week contract.
Spurs are therefore in a strong negotiating position should Levy sanction his departure, but the chairman remains reluctant to lose the club's prized asset, even for what would be one of the biggest transfer fees in history.
Sources said Kane is hopeful the situation can be resolved before the start of Euro 2020 on June 11, however, and that confidence could be based on unconfirmed reports suggesting he was keen to move on last summer but was convinced by Levy to give the club one more year in return for a softer stance at the end of this season should he still want to find a new club.
A club spokesperson declined to comment directly on Kane's future, telling ESPN: "Our focus is on finishing the season as strongly as possible. That's what everyone should be focused on."
If Spurs are to grant their captain's wish, they would prefer he go to a club abroad rather than strengthen a domestic rival, but Kane's main suitors are all likely to be English.
Levy has a difficult relationship with Chelsea arising from previous transfers, however, which might therefore hand an advantage to United or City.
Fans have protested at the owners, ENIC, and Levy's handling of the club in the wake of their involvement in the failed Super League project, and about 10,000 supporters will be able to attend their final home game against Aston Villa on Wednesday once coronavirus restrictions are lifted.