The RB Leipzig star suffered a sprain of his left knee and won't be able to return to take part as France look to defend their title in Qatar. The reigning World Cup holders on Tuesday confirmed Eintracht Frankfurt's Randal Kolo Muani had been called up as a replacement.
France will play their opening game against Australia on Nov. 22. FIFA regulations allow teams to replace an injured player up to 24 hours before their first match.
On Monday, France announced the call-ups of Borussia Monchengladbach striker Marcus Thuram and Monaco defender Axel Disasi. Disasi made the squad after Paris Saint-Germain centre back Presnel Kimpembe ruled himself out because of a hamstring injury.