Christian Pulisic will lead a young United States squad in Monday's friendly against Bolivia, as one of four teenagers in the starting XI.
Josh Sargent, 18, will start up front to earn his first senior cap with the national team, after starring for the under-17 and under-20 teams last year.
He's joined by fellow 18-year-old Timothy Weah, who gets his first start after a cameo substitute appearance in March, and 19-year-olds Pulisic and Weston McKennie, who made his first U.S. start last November.
Pulisic will make the 21st national team appearance of his young career, making him the joint-most experienced player in the squad alongside Joe Corona.
Also making their senior debuts are Toronto FC goalkeeper Alex Bono, Manchester City's Erik Palmer-Brown, and Everton's Antonee Robinson.
The average age of the U.S.'s starters is just 22 years old.
Manchester United defender Matthew Olosunde and Benfica's Keaton Parks, both 20, could also make their first appearances as substitutes.
The starting XI:
Goalkeeper: Alex Bono (Toronto FC)
Defenders: Eric Lichaj (Notthingham Forest), Walker Zimmerman (LAFC), Erik Palmer-Brown (Manchester City), Antonee Robinson (Everton);
Midfielders: Weston McKennie (Schalke); Tim Weah (Paris Saint-Germain), Joe Corona (America), Christian Pulisic (Borussia Dortmund), Rubio Rubin (Tijuana)
Forward: Josh Sargent (Werder Bremen)