Ecuador maintained their perfect start to CONMEBOL World Cup qualifying with a 2-1 defeat of previous co-leaders Uruguay in Quito on Thursday.
Goals from Felipe Caicedo and Fidel Martinez sandwiched Edinson Cavani's 49th-minute strike to maintain the hosts' 100 percent record in their qualifying campaign.
Caicedo sent the home side into raptures in the 23rd minute. After receiving a defence-splitting through-ball on the right of the box, Juan Carlos Paredes rolled his cross into Caicedo's path before the Espanyol forward slotted underneath Fernando Muslera.
Cavani levelled the score four minutes after the break. The PSG man headed into Alexander Dominguez's net following a Nicolas Lodeiro free kick.
Ecuador, which showed attacking intent all game, wouldn't be denied, and got the winner just 10 minutes later through a Fidel Martinez tap-in after Muslera parried a well-hit Jefferson Montero shot into his path.
James Rodriguez's 68th-minute strike cancelled out an Arturo Vidal first-half header to earn Colombia a 1-1 draw against Chile in Santiago.
The draw lifted Chile into second place in the table with seven points, while Colombia went level with Paraguay in fourth.
Vidal opened the scoring in the 45th minute, with the Bayern Munich man placing a powerful downward header into David Ospina's bottom corner.
Rodriguez secured the deserved point for the visitors 13 minutes after the break, latching on to a loose ball in the box, pivoting and firing a low shot inside Claudio Bravo's near post.
Earlier in the day, Bolivia collected their first win in a 4-2 victory over Venezuela in La Paz.
Rodrigo Ramallo, Juan Arce and Rudy Cardozo Fernandez scored for the home side, while Mario Rondon and Richard Blanco bagged consolation goals for the Venezuelans.
The win leaves Bolivia on three points from three games. Venezuela sit bottom of the table, failing to record a point.
Brazil and Argentina's match was postponed due to heavy rain Buenos Aires. The match was rescheduled for Friday, Nov. 13 at 7 p.m. ET.