2022 NCAA Tournament: Everything you need to know to bet the Final Four

Paolo Banchero has been a star during the NCAA tournament and will look to lead the Duke Blue Devils to their first national championship since 2015. Photo by Jared C. Tilton/Getty Image

The field for the 2022 NCAA Men's Final Four is set for Saturday night. While only one No. 1 seed will be represented in New Orleans, the two semifinal games will feature some of the most storied schools in the history of college basketball.

No. 8 seed North Carolina will take on No. 2 seed Duke for the first time in NCAA tournament history in what could be the final game of legendary coach Mike Krzyzewski's career. The two teams played each other five weeks ago at Cameron Indoor Stadium, where Hubert Davis' squad pulled off a 94-81 upset in front of a star-studded Blue Devil crowd. Now, the latest chapter of the rivalry takes center stage from Caesars Superdome for a shot at an NCAA championship.

The earlier Final Four matchup features No. 1 seed Kansas and No. 2 seed Villanova. The matchup will feature two prolific offenses and disciplined basketball teams. Led by legendary coaches Bill Self and Jay Wright the matchup is sure to provide plenty of thrilling with Jayhawk star Ochai Agbaji leading the way.

Here's everything you need to know to make a bet on the NCAA Final Four this weekend.

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Final Four Picks

Men's NCAA tournament - Best bets for the Final Four

Will this be Coach K's last hurrah? Can Nova advance to yet another title game? Our experts offer their best bets for the semifinals.

Women's NCAA tournament - Best bets for the Final Four

Which teams are worth wagering on in the women's Final Four? Charlie Creme and Monica McNutt weigh in.

What experts got right and wrong in Final Four picks

We look back and what our experts predicted correct and got wrong ahead of the Final Four on Saturday.

Final Four Analysis

Duke vs. North Carolina: History, nostalgia and betting tips the Final Four matchup

Dalen Cuff takes a look at the highly anticipated Duke-UNC NCAA Final Four matchup from a betting perspective.

Final Four betting notes: Villanova's strong history against Kansas

Your essential guide to betting notes and history heading into the men's NCAA Final Four.

Women's Final Four 2022: How each team in Minneapolis can win the national title

Charlie Creme looks at the strengths and weaknesses of all four teams heading into the final weekend of March Madness in Minneapolis.

March Madness: First look at the 2022 men's Final Four teams

Myron Medcalf breaks down the four teams left in the NCAA men's tournament and how each can reach the National Championship game.

Duke goes into Final Four as national title favorite

The Duke Blue Devils enter the 2022 NCAA Final Four as favorites over rival UNC and the favorite to win the National Championship on April 4.

$3.1B expected to be wagered on NCAA Tournament

The America Gaming Association projects that 45 million people will spend over $3B on the NCAA tournament through bracket pools and wagers with sportsbooks and friends. The $3.1 billion amount is approximately three times more than how much was estimated to have been bet on this year's Super Bowl with U.S. sportsbooks.

Men's NCAA Tournament Challenge trends and notes

Everything you need to know about the NCAA men's tournament including news, trends and history of the Tournament Challenge picks made.

Women's 2022 Tournament Challenge Bracket notes and trends

Everything you need to know about the NCAA women's tournament including news, trends and history of the Tournament Challenge picks made.