McNeill led the Hawks for three seasons with a 59-38 record. Hartford was 23-11 this season, and the program made its first postseason bid since 2013, losing to Providence in the WNIT.
She will succeed interim coach Nicole Mealing, who was the third person to coach ECU (16-15) since September.
Mealing took over the program in late December after Chad Killinger stepped down for health reasons. Killinger had taken the interim job in October after the resignation of Heather Macy amid an investigation into possible NCAA violations related to practices.