ESPN
    • NFL
    • NCAAF
    • MLB
    • NBA
    • Soccer
    • WNBA
    • NHL
    • More Sports
    • Watch ESPN
      Watch
    • ESPN Fantasy
      Fantasy
    • Where to Watch
    • Search

    Los Angeles Chargers @ Buffalo Bills

    LAC
    Los Angeles ChargersChargersLAC
    0-2, 0-0 Away
    BUF
    Buffalo BillsBillsBUF
    2-0, 1-0 Home
    • Gamecast
    • Preview
    • Videos
    • Odds
    • TicketsExternal Link

    Game Odds
    Odds by

    2026-09-27T17:00ZOpenSpreadTotalML
    Los Angeles ChargersLos Angeles ChargersLAC
    (0-2)
    (0-2)
    o48.5
    -110
    +7
    -105
    o50.5
    -105
    +260
    Buffalo BillsBuffalo BillsBUF
    (2-0)
    (2-0)
    -2.5
    -110
    -7
    -115
    u50.5
    -115
    -325
    See More Odds

    Recent Schedule

    DATEOPPRESULTSPREADTOTAL
    9/20vsLVL26-14-6.543.5
    9/13vsARIL26-14-8.547.5
    8/27vsLARL20-18-3.537.5
    8/20vsSFL41-17-1.538.5
    8/13@HOUW27-7+1.538.5

    Matchup Predictor

    Los Angeles Chargers
    Buffalo Bills
    21.7
    %

    LAC

    78.1
    %

    BUF

    According to ESPN Analytics

    Betting 101

    The Beginner's Guide to BettingReady to enter the world of sports betting? Here's everything you need to know to get started.
    James Cook III
    BUF RB
    Josh Allen
    BUF QB
    Omarion Hampton
    LAC RB
    DJ Moore
    BUF WR
    Dalton Kincaid
    BUF TE
    Khalil Shakir
    BUF WR
    Ladd McConkey
    LAC WR
    Oronde Gadsden
    LAC TE
    FIRST TD
    Anytime TD
    2+ TDs
    +425
    -185
    +300
    +550
    -140
    +380
    +650
    -120
    +500
    +950
    +160
    +1300
    +1000
    +175
    +1400
    +1100
    +195
    +1600
    +1500
    +195
    +1600
    +1700
    +225
    +2000
    See More Odds
    Josh Allen
    BUF QB
    Justin Herbert
    LAC QB
    o237.5
    -112
    u237.5
    -112
    o226.5
    -113
    u226.5
    -111
    See More Odds
    James Cook III
    BUF RB
    Omarion Hampton
    LAC RB
    Josh Allen
    BUF QB
    Justin Herbert
    LAC QB
    o79.5
    -113
    u79.5
    -111
    o60.5
    -112
    u60.5
    -112
    o34.5
    -113
    u34.5
    -111
    o20.5
    -109
    u20.5
    -115
    See More Odds
    Ladd McConkey
    LAC WR
    Dalton Kincaid
    BUF TE
    DJ Moore
    BUF WR
    Khalil Shakir
    BUF WR
    Oronde Gadsden
    LAC TE
    Quentin Johnston
    LAC WR
    o58.5
    -110
    u58.5
    -114
    o56.5
    -112
    u56.5
    -112
    o49.5
    -111
    u49.5
    -113
    o40.5
    -112
    u40.5
    -112
    o37.5
    -113
    u37.5
    -111
    o36.5
    -111
    u36.5
    -113
    See More Odds
    Buffalo Bills
    2-0
    Los Angeles Chargers
    0-2
    o19.5
    -750
    u19.5
    +500
    o10.5
    -800
    u10.5
    +550
    See More Odds

    Injury Report

    Los Angeles Chargers
    NameStatus
    Rodney ShelleyR. ShelleyCB
    QuestionableHamstring
    Dalvin TomlinsonD. TomlinsonDT
    OutHamstring
    Trey Pipkins IIIT. Pipkins IIIOT
    OutKnee
    Elijah MoldenE. MoldenCB
    OutHamstring
    Kayode AwosikaK. AwosikaG
    OutLower Leg
    Buffalo Bills
    NameStatus
    Keon ColemanK. ColemanWR
    QuestionableAnkle
    DJ MooreD. MooreWR
    QuestionableShoulder - AC Joint
    Ed OliverE. OliverDT
    QuestionableHip
    Ar'maj Reed-AdamsA. Reed-AdamsG
    QuestionableElbow
    T.J. SandersT.J. SandersDT
    Out
    Full Injury Report

    Super Bowl Winner

    TEAMODDS
    LARLAR+620
    BUFBUF+750
    BALBAL+950
    SEASEA+1000
    SFSF+1050
    KCKC+1100
    PHIPHI+1600
    CINCIN+1700
    TEAMODDS
    DETDET+2000
    NENE+2000
    DENDEN+2000
    HOUHOU+2200
    DALDAL+2400
    JAXJAX+2500
    MINMIN+2600
    CHICHI+3000
    See More NFL Futures
    Top Betting Headlines
    • Top-seeded Lynx heavy favorites to win WNBA title with playoffs set
    • Rozier's mother to court: Allow Terry to return to NBA
    • New York calls Polymarket 'unlicensed gambling operation' in lawsuit
    • Gators coach on being fave vs. Ole Miss: 'Lot of good drugs out there'
    • Federal prosecutors identify 18 allegedly rigged pitches for Clase trial
    • Leagues, unions urge action against escalating threats from bettors
    • Sweeney's Novig ad criticized for sexualizing women in sports
    • Zverev, Sabalenka favorites to win US Open titles
    • Super Bowl favorite Rams drawing the most bets
    • Allen, Jackson, Burrow lead NFL MVP faves; non-QBs top OROY odds
    ESPN
    • Terms of Use
    • Privacy Policy
    • Your US State Privacy Rights
    • Children's Online Privacy Policy
    • Interest-Based Ads
    • About Nielsen Measurement
    • Your Privacy Choices
    • Contact Us
    • Disney Ad Sales Site
    • Work for ESPN
    • Corrections
    GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Call 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in ONT. Eligibility restrictions apply. Terms: draftkings.com/sportsbook. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL.
    Copyright: © 2026 ESPN Enterprises, LLC. All rights reserved.