Defenders Tim Ream and Mark McKenzie were the only holdovers from the as U.S. coach Gregg Berhalter changed nine starters for Wednesday night's exhibition, with Pulisic, Weston McKennie and Giovanni Reyna all on the bench.
The U.S. took the lead inside of 10 minutes when the Red Bull Salzburg's Brenden Aaronson finished off a counter-attack with a thunderous shot from close range after the ball fell to him in the penalty area.
Berhalter's side dominated proceedings throughout the first half and found a second just before the break with a composed finish from Daryl Dike -- who will be back with Orlando City after his loan spell at Barnsley earlier this year.
It was Dike's first senior international goal in just his third appearance and the U.S. took a 2-0 lead into the dressing room.
The hosts picked up right where they left off after the break as Reggie Cannon pounced on a careless pass from Costa Rica, darted into the box and slotted home with his left foot for his first career international tally.
Reyna, who scored in the victory over Mexico, came off the substitutes' bench and won, then converted a penalty to extend the U.S. lead to four goals.
Defender Mark McKenzie, the target of racial abuse on the Internet after a poor first half Sunday, was the only player to start for the fourth straight game and had a stronger effort.
"I came of out of the Mexico game being extremely proud of Mark and the way he handled himself," Berhalter said. "He didn't need to play another minute today and I still would have been proud of him."
The loss would end up being the final game in charge for Ticos coach Ronald Gonzalez, with the Costa Rican football federation confirming after the match that a "unanimous" decision was made to part ways with the 50-year-old.
It was the fourth match in a grueling 11 days for the U.S., designed to mimic the compressed World Cup qualifying scheduled caused by the coronavirus pandemic. It was also the 11th win in the last 13 matches for the U.S. in which they outscored opponents 39-9.
The team travelled 5.400 miles between Europe and the Rocky Mountain West in the U.S. to play the four matches, winning three times, including the CONCACAF Nations League trophy. Twenty-four players saw action, and eight scored.
The 14-match final round of the CONCACAF region opens for the U.S. on Sept. 2 at El Salvador or St. Kitts and Nevis, followed by a home game on Sept. 5 against Canada or Haiti and a Sept. 8 match at Honduras.
Information from the Associated Press was used in this report.