Bolivia scored twice in the first half then missed a penalty and had a man sent off in a 3-0 win over Uruguay on Tuesday.
With Brazil into the World Cup and Argentina on the verge, teams such as Ecuador, Colombia, Chile, and Uruguay are fighting for their spots.
Chile and Bolivia have the chance to get back into World Cup contention with two crucial home games over the next few days.
Brazil are leading the way in CONMEBOL qualifying, but what about the rest as this week's tripleheaders see two-thirds of games complete?
Lionel Messi scored a hat-trick to give Argentina a 3-0 win over Bolivia, moving him above Pele as South America's top male all-time scorer.
The suspension of Argentina vs. Brazil took the spotlight off a competitive South American World Cup qualifying, but all eyes are back on the pitch.
Giorgian de Arrascaeta scored twice as Uruguay beat Bolivia 4-2 on Sunday to boost their chances of qualifying for the World Cup.
Substitute Fernando Saucedo scored a stunning late goal to give home side Bolivia a 1-1 draw against Colombia in their World Cup qualifier.
Brazil are comfortably out front of South America's World Cup qualifying campaign, but behind them, a lot could change between now and Qatar 2022.
Neymar is in form, Leo Messi is breaking records, but it's the displays of Ricardo Gareca's Peru that have been the talk of the Copa group stage.
Lionel Messi scored twice as Argentina beat Bolivia 4-1 on Monday to set up a Copa America quarter-final against Ecuador.
An own goal in the first half and a late second from Edinson Cavani gave Uruguay a 2-0 win over Bolivia on Thursday at the Copa America.
Uruguay's Facundo Torres and Ecuador's Gonzalo Plata may be inconsistent, but they are making people sit up and take notice at the Copa America.
There were 140 known COVID-19 cases at the Copa America in Brazil on Monday, up from 66 positive tests on Thursday.
Chile secured a 1-0 win over Bolivia with a goal from English-born striker Ben Brereton in their Copa America clash on Friday.
The second set of Copa America matches saw Argentina get their first win of the tournament while hosts Brazil scored another big victory.
Half of the teams playing the Copa America -- Venezuela, Bolivia, Colombia, Peru and Chile -- have confirmed at least one positive test.
The first set of Copa America matches have concluded. As Brazil still struggles with COVID-19 cases, the on-field action is officially underway.
Paraguay went behind to an early penalty but scored three times in the second half for a 3-1 win over Bolivia in Monday's Copa America opener.
After a long and controversial saga, the Copa America will kick off. Will Brazil repeat as winners or can Lionel Messi lead Argentina to glory?
Brazil's Supreme Court on Thursday rejected all three injunctions sought to prevent the Copa America tournament being held in the country.
Mastercard Inc and drinks company Ambev, major sponsors of South American football, backed away from the Copa America on Wednesday.
Members of the Brazil soccer team have criticised CONMEBOL's last-minute decision to host the Copa America amid the deadly coronavirus pandemic.
Two rounds of South American World Cup qualifiers will be played "in the days before the Copa America" begins on June 13, says CONMEBOL.
A Chinese pharmaceutical company will donate 50,000 doses of their COVID-19 vaccine for national teams to use ahead of the Copa America.