Ramirez also homered from both sides of the plate during a 9-2 victory over Kansas City on July 26. According to STATS, he is the first player in major league history to accomplish the feat twice within his team's first 15 games of the season.
"We've heard people say the Indians aren't going to hit, but we know we're going to be good for the rest of the season," Ramirez said. "We have a very good group of hitters. As long as we do our job, we know the pitchers are going to do theirs and we'll be fine."
Cesar Hernandez had the big blow in the seventh, clearing the bases with a three-run double. Franmil Reyes added a two-run single, helping Cleveland reach double-digits in an inning for the first time since Sept. 28, 2018 at Kansas City.
Ramirez also had an RBI triple in the third and scored four times. He was named the MVP of the annual Ohio Cup series after driving in six runs during the four-game set, one more than Cincinnati's total.
"Our team doesn't need a wake-up call, we just need to play better, and we will," Reds manager David Bell said. "Nobody likes to get beat whether it's by one run or by any score, they all count the same."
Carlos Carrasco (2-1) allowed one hit over six innings -- equaling his longest outing since returning from chronic myeloid leukemia last Sept. 1 -- and combined with three relievers to blank Cincinnati for the second night in a row.
"There is a little competition between our pitchers, but we never talk about it," Carrasco said. "It's a lot of fun seeing the other guys throw zeroes after zeroes and pitching great. You get emotional, man, seeing your teammates doing their thing."
The Indians were without manager Terry Francona for the fifth straight game because of a gastrointestinal problem that he has experienced for months. First base coach Sandy Alomar Jr. filled in for the 61-year-old Francona, who will not travel with the team to Chicago.
Reds right fielder Nick Castellanos went 0 for 4, ending his season-opening hitting streak at 12 games.
Castillo (0-2) struck out nine in five innings, allowing three runs and walking four. Reds infielder Matt Davidson pitched the ninth, giving up one hit, in his fourth career appearance on the mound.
Bell was ejected by home plate umpire Jerry Meals in the sixth after Winker was called out on a third strike to end the inning.
"You're trying to grind out runs and the pressure kind of escalates on everyone, myself included," Cincinnati catcher Tucker Barnhart said. "It's human nature. It's something as players we try as hard as we can to not do, but it's something that happens."
THREE FOR ALL
Reds right-hander Jose De Leon issued three bases-loaded walks in the seventh, mere hours after being promoted from the taxi squad. He is wearing No. 87 because his birthday is Aug. 7.
Once a top-tier Dodgers prospect, the 27-year-old had only appeared in three games in the majors since undergoing Tommy John surgery in 2018.
Reds: 2B Mike Moustakas (left quadriceps bruise) missed his second game in a row after being injured Tuesday against Cleveland. Bell is confident Moustakas will return to action over the weekend.
Indians: OF Delino DeShields (coronavirus) was reinstated from the injured list and made his season debut, batting ninth and playing center. His father, Delino Sr., is Cincinnati's first base coach.
Reds: RHP Trevor Bauer (1-0, 0.68 ERA) starts the opener of a three-game series in Milwaukee. The National League ERA leader tossed a two-hit shutout over seven innings Sunday during a doubleheader at Detroit.
Indians: RHP Aaron Civale (1-1, 3.75 ERA) takes the hill in the opener of a three-game set against the White Sox. He is 1-4 with a 3.46 ERA in seven career road starts.
More AP MLB: https://apnews.com/MLB and https://twitter.com/AP-Sports
Perez breaks Bench's record with 46th HR, KC tops Indians
— Salvador Perez hit his 46th home run, breaking Johnny Bench’s record for homers by a catcher in a season, and the Kansas City Royals beat the Cleveland Indians 7-2 Monday in the first game of a doubleheader.
Salvador Perez sets single-season HR record for catchers
Salvador Perez passes Johnny Bench for the most long balls in a season by a catcher, and also ties Vladimir Guerrero Jr. atop the 2021 home run leaderboard.
Right fielder Adam Engel 'feels good,' will be activated by Chicago White Sox with playoffs on horizon
At long last, the White Sox will have their starting outfield back in full, as right fielder Adam Engel is set to be activated from the injured list on Tuesday, according to Chicago manager Tony La Russa.
Anthony Gose, 31, former outfielder converted to reliever, promoted by Cleveland Indians
Formerly an outfielder in the big leagues, Anthony Gose, who played for Team USA in the Tokyo Olympics, was called up from the minors by the Cleveland Indians on Monday, this time as a hard-throwing lefty reliever.
Struggling New York Yankees activate pitcher Luis Severino, send former All-Star to bullpen
Former All-Star pitcher Luis Severino was activated by the New York Yankees before Monday's series opener against the Texas Rangers and is in position to make his first major league appearance in nearly two years.
Top six adds for fantasy baseball playoff matchups
If you're in your fantasy finals matchup, or needing just a little push in roto leagues, Tristan offers six players with something to prove this week.