Aron Baynes scored 16 points, and Danny Green and Marco Belinelli each added 12 points in San Antonio's preseason finale. Tim Duncan had six points and eight rebounds in 23 minutes, while Tony Parker had eight points and four assists in 20 minutes.
Howard and Harden played all but the final minute of the third quarter, and the Rockets outscored the Spurs 37-25 in the period.
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Check out the highlights from Donovan Mitchell's 2020 playoffs in which he averaged over 36 points and took the Nuggets to the brink in Game 7.
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The 76ers are in talks with former Rockets general manager Daryl Morey to run their basketball operations, sources told ESPN.