A stunning overtime victory over the Bears was a good start.
Jackson set up Dan Carpenter's field goal in overtime with a 38-yard run to the 1 and the Buffalo Bills surprised Chicago 23-20 on Sunday.
The veteran running back ran for just 61 yards, but he came through with a big one at the end.
"I am old, but I can still play," the 33-year-old Jackson said.
The Bears had just punted to open the extra period and Buffalo took over on its own 22 to start the winning possession. The Bills got the ball to the Chicago 39 when the 33-year-old Jackson turned toward the left side and broke off his big run, pushing safety Chris Conte out of the way twice inside the 10 before being knocked out of bounds at the 1.
Buffalo's EJ Manuel backed up 3 yards and put the ball in the middle of the field. After a delay of game, Carpenter won it with a 27-yarder. It was a good start for the Bills as they enter a new era following the death of founding father and Hall of Fame owner Ralph Wilson. They're trying to end a 14-year playoff drought and they started by knocking off a team eyeing a run to the postseason.
"It's so difficult to win on the road in this league, especially on opening day I think it's even tougher," Marrone said. "I'm proud of them. It was different, I'm not going to lie to you. It was different in that locker room before the game."
Jackson said, "It was a great statement win for us to put all that stuff behind and focus on the season."
This was not what the Bears had in mind. They got little pressure from a revamped defense despite the addition of five-time Pro Bowl end Jared Allen, and there were some questionable decisions at times by Jay Cutler, who got picked off twice while throwing for 349 yards and two touchdowns.
The Bears trailed 17-7 at the half after Buffalo scored 17 unanswered points and came up short down the stretch after tying it.
The Bills looked like they might pull this one out in regulation with a 20-17 lead after Dan Carpenter kicked a 33-yard field goal.
But the Bears answered after the Bills grabbed the lead.
They drove from the 20 to the Buffalo 19, and Cutler threw an incomplete pass to Brandon Marshall in the end zone before Robbie Gould tied it with a 37-yard field goal with 30 seconds left in regulation.
"You guys are going to be as negative as possible," a surly Cutler said. "But we've got a lot of games left, we did a lot of good things. Obviously we made mistakes today and we've got to clean them up and got to keep it going."
Manuel completed 16 of 22 passes for 173 yards for Buffalo. He also had a 2-yard touchdown run in the first quarter.
Robert Woods added 78 yards receiving.
Chicago's Matt Forte ran for 82 yards and had 87 receiving. Brandon Marshall caught eight passes for 71 yards and a touchdown. Alshon Jeffery also had 71 yards receiving, although he spent most of the second half on the sideline because of a hamstring injury.
It wasn't a great afternoon for a revamped defense, either. Allen, the star addition in the offseason overhaul, was a nonfactor in his Bears debut. But Trestman thought it was a good day overall for that group _ Jackson's long run aside.
"At the end of the day you keep them in the 17 to 20-point range, that should be enough for us to win," he said. "And if we hang onto the football, take care of it we would have been in a good position to do that."
NOTES: Bills LB Keith Rivers left the game because of a groin injury and S Aaron Williams was being evaluated for a concussion afterward. Buffalo also held out CB Stephon Gilmore because of a nagging groin injury. ... Trestman thought Jeffery might return at some point in the second half, but that didn't happen. ... Slauson and Garza did not think they were seriously injured.
Steelers vs. Lions: Some VERY early NFL preseason action
Watch what happens when JuJu Smith-Schuster attempts to play tug-of-war with a real lion.
Tom Brady talks Tampa Bay Buccaneers' Super Bowl boat parade on late-night TV
Tom Brady told James Corden that he doesn't remember much about his notable Lombardi Trophy toss at the Bucs' Super Bowl parade, but Brady did credit his daughter, Vivi, for being the voice of reason when she said, "Daddy, no!" before the heave.
New York Jets release defensive end Henry Anderson
By cutting DE Henry Anderson, the Jets now have more than $75 million in cap space as they prepare for free agency.
J.J. Watt's covert T-shirt plan to keep his free-agent destination secret
Watt announced he was heading to the Cardinals via social media, but he needed help to keep it under wraps.
Minnesota Vikings release TE Kyle Rudolph after 10 seasons
Minnesota Vikings tight end Kyle Rudolph, the team's second-round pick in 2011, was released Tuesday in a move that will save them $5.1 million against the salary cap in 2021.
J.J. Watt says all signs kept pointing toward Arizona Cardinals
J.J. Watt said Tuesday all signs kept pointing back to the Cardinals during his recruitment process and that he believes in quarterback Kyler Murray.