BuffaloSabres
- 50-23-9
- 1st in Atlantic Division
Buffalo Sabres Schedule 2021-22
| DATE | OPPONENT | RESULT | W-L-OTL | Goalie | Top Performer |
| Thu, Oct 14 | W5-1 | 1-0-0 | Anderson | Anderson | |
| Sat, Oct 16 | vs | W2-1 SO | 2-0-0 | Tokarski | Tokarski |
| Tue, Oct 19 | W5-2 | 3-0-0 | Anderson | Anderson | |
| Fri, Oct 22 | L4-1 | 3-1-0 | Anderson | Olofsson | |
| Sat, Oct 23 | L2-1 OT | 3-1-1 | Tokarski | Tokarski | |
| Mon, Oct 25 | W5-1 | 4-1-1 | Anderson | Anderson | |
| Thu, Oct 28 | W4-3 OT | 5-1-1 | Anderson | Asplund | |
| Sun, Oct 31 | L3-2 | 5-2-1 | Tokarski | Olofsson | |
| Tue, Nov 2 | L5-3 | 5-3-1 | Anderson | Skinner | |
| Thu, Nov 4 | L5-2 | 5-4-1 | Tokarski | Cozens | |
| Sat, Nov 6 | L4-3 OT | 5-4-2 | Tokarski | Asplund | |
| Mon, Nov 8 | L5-3 | 5-5-2 | Tokarski | Miller | |
| Fri, Nov 12 | W3-2 | 6-5-2 | Tokarski | Tokarski | |
| Sat, Nov 13 | L5-4 | 6-6-2 | Dell | Skinner | |
| Tue, Nov 16 | W2-1 | 7-6-2 | Tokarski | Tokarski | |
| Thu, Nov 18 | L5-0 | 7-7-2 | Tokarski | Dell | |
| Sun, Nov 21 | L5-4 | 7-8-2 | Dell | Dahlin | |
| Mon, Nov 22 | L7-4 | 7-9-2 | Dell | Thompson | |
| Wed, Nov 24 | L5-1 | 7-10-2 | Dell | Tokarski | |
| Fri, Nov 26 | W4-1 | 8-10-2 | Tokarski | Tokarski | |
| Sat, Nov 27 | L3-2 OT | 8-10-3 | Tokarski | Tokarski | |
| Mon, Nov 29 | L7-4 | 8-11-3 | Tokarski | Murray | |
| Thu, Dec 2 | L7-4 | 8-12-3 | Dell | Hinostroza | |
| Sat, Dec 4 | L6-2 | 8-13-3 | Subban | Olofsson | |
| Tue, Dec 7 | L2-0 | 8-14-3 | Luukkonen | Thompson | |
| Fri, Dec 10 | L2-1 | 8-15-3 | Luukkonen | Luukkonen | |
| Sat, Dec 11 | L3-2 SO | 8-15-4 | Luukkonen | Luukkonen | |
| Tue, Dec 14 | W4-2 | 9-15-4 | Luukkonen | Luukkonen | |
| Thu, Dec 16 | W3-2 SO | 10-15-4 | Luukkonen | Luukkonen | |
| Fri, Dec 17 | L3-2 OT | 10-15-5 | Subban | Subban | |
| Mon, Dec 20 | Postponed | ||||
| Wed, Dec 22 | Postponed | ||||
| Thu, Dec 23 | Postponed | ||||
| Mon, Dec 27 | Postponed | ||||
| Wed, Dec 29 | L4-3 | 10-16-5 | Luukkonen | Thompson | |
| Thu, Dec 30 | L4-1 | 10-17-5 | Subban | Okposo | |
| Sat, Jan 1 | L4-3 OT | 10-17-6 | Luukkonen | Tuch | |
| Thu, Jan 6 | L3-2 | 10-18-6 | Luukkonen | Dahlin | |
| Sat, Jan 8 | Postponed | ||||
| Tue, Jan 11 | L6-1 | 10-19-6 | Luukkonen | Miller | |
| Thu, Jan 13 | W4-1 | 11-19-6 | Dell | Dell | |
| Sat, Jan 15 | L4-0 | 11-20-6 | Dell | Dell | |
| Mon, Jan 17 | L3-2 OT | 11-20-7 | Dell | Skinner | |
| Tue, Jan 18 | W3-1 | 12-20-7 | Houser | Houser | |
| Thu, Jan 20 | L5-4 | 12-21-7 | Dell | Dahlin | |
| Sat, Jan 22 | W6-3 | 13-21-7 | Houser | Krebs | |
| Tue, Jan 25 | L5-0 | 13-22-7 | Dell | Dell | |
| Sat, Jan 29 | @ | W3-1 | 14-22-7 | Anderson | Anderson |
| Sun, Jan 30 | L4-1 | 14-23-7 | Tokarski | Skinner | |
| Tue, Feb 1 | L5-2 | 14-24-7 | Anderson | Hayden | |
| Thu, Feb 10 | L4-3 OT | 14-24-8 | Tokarski | Tuch | |
| Sun, Feb 13 | W5-3 | 15-24-8 | Anderson | Skinner | |
| Tue, Feb 15 | W6-3 | 16-24-8 | Tokarski | Cozens | |
| Thu, Feb 17 | L3-1 | 16-25-8 | Anderson | Anderson | |
| Sat, Feb 19 | L5-3 | 16-26-8 | Tokarski | Thompson | |
| Sun, Feb 20 | L7-3 | 16-27-8 | Anderson | Okposo | |
| Wed, Feb 23 | L4-0 | 16-28-8 | Anderson | Samuelsson | |
| Fri, Feb 25 | L5-3 | 16-29-8 | Tokarski | Cozens | |
| Sun, Feb 27 | L4-2 | 16-30-8 | Anderson | Eakin | |
| Wed, Mar 2 | W5-1 | 17-30-8 | Anderson | Anderson | |
| Fri, Mar 4 | W5-4 | 18-30-8 | Anderson | Skinner | |
| Sun, Mar 6 | L3-0 | 18-31-8 | Tokarski | Tokarski | |
| Mon, Mar 7 | L6-1 | 18-32-8 | Anderson | Hayden | |
| Thu, Mar 10 | W3-1 | 19-32-8 | Anderson | Anderson | |
| Sun, Mar 13 | W5-2 | 20-32-8 | Anderson | Hinostroza | |
| Thu, Mar 17 | L6-1 | 20-33-8 | Anderson | Olofsson | |
| Fri, Mar 18 | W1-0 OT | 21-33-8 | Tokarski | Tokarski | |
| Sun, Mar 20 | W3-2 OT | 22-33-8 | Anderson | Anderson | |
| Wed, Mar 23 | W4-3 SO | 23-33-8 | Anderson | Thompson | |
| Fri, Mar 25 | L4-3 SO | 23-33-9 | Tokarski | Skinner | |
| Sun, Mar 27 | L5-4 OT | 23-33-10 | Anderson | Samuelsson | |
| Mon, Mar 28 | W6-5 | 24-33-10 | Tokarski | Olofsson | |
| Wed, Mar 30 | L3-2 SO | 24-33-11 | Anderson | Girgensons | |
| Fri, Apr 1 | W4-3 | 25-33-11 | Anderson | Thompson | |
| Sun, Apr 3 | L5-3 | 25-34-11 | Tokarski | Okposo | |
| Tue, Apr 5 | W4-2 | 26-34-11 | Anderson | Anderson | |
| Thu, Apr 7 | L5-3 | 26-35-11 | Anderson | Skinner | |
| Fri, Apr 8 | L4-3 | 26-36-11 | Tokarski | Olofsson | |
| Sun, Apr 10 | L5-0 | 26-37-11 | Anderson | Tuch | |
| Tue, Apr 12 | W5-2 | 27-37-11 | Anderson | Dahlin | |
| Thu, Apr 14 | L6-2 | 27-38-11 | Anderson | Asplund | |
| Sat, Apr 16 | W4-3 | 28-38-11 | Anderson | Jokiharju | |
| Sun, Apr 17 | W5-3 | 29-38-11 | Tokarski | Dahlin | |
| Thu, Apr 21 | W5-2 | 30-38-11 | Anderson | Olofsson | |
| Sat, Apr 23 | W5-3 | 31-38-11 | Tokarski | Thompson | |
| Thu, Apr 28 | L5-0 | 31-39-11 | Tokarski | Asplund | |
| Fri, Apr 29 | W3-2 OT | 32-39-11 | Tokarski | Mittelstadt | |