Vitesse defeated Tottenham Hotspur 1-0 in Europa Conference League group stage action thanks to a second-half goal from Maximilian Wittek.
Playing without Harry Kane or Son Heung-Min, Spurs lost their first group stage match in the inaugural season of UEFA's newest club competition.
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The Dutch hosts earned the deserved win over a rotated Spurs side, with the Dutch club finding the match winner in the 78th minute. Eliazer Dasa lifted a great ball for Wittek, who then hit a first-time effort into the back of the net.
Spurs' best opportunity came moments after halftime, when Bryan Gil rattled the woodwork.
Nuno Espirito Santo's side are third after three matches in Group G, with a draw against with French side Rennes and a victory over Slovenian minnows Mura in their opening two games.
Only the group winner automatically goes through to the last 16 of the competition.