- Victor Osimhen (9', 51')
- Khvicha Kvaratskhelia (35' Pen)
- Tanguy Ndombele (68')
The Naples side have a 21-point lead over second-placed Inter Milan, who host Juventus later on Sunday.
Luciano Spalletti's Napoli team took the lead after nine minutes when Piotr Zielinski's corner found Oshimen in the centre of the box and he headed into the bottom left corner.
Kvaratskhelia doubled the lead in the 35th minute with a penalty after being fouled by Karol Linetty.
Oshimen scored his second and reached a league-leading 21 goals this season six minutes into the second half with another header following Mathias Olivera's cross.
Substitute Ndombele made it 4-0 with his first Serie A goal in the 68th when Kvaratskhelia set him up in the centre of the box and the France international slotted home.
- Matteo Marchetti