Esteghlal emerged from a tough Group C on the final day of matches while Xavi's Al Sadd couldn't get enough help to advance.
Al Nassr booked their ticket with a win over Al Sadd, while three sides have a shot in Group C. Here's a look ahead of the final day of matches.
Tournament debutants Istiklol picked up their first-ever win in the AFC Champs League moving them into a share of the top spot in Group A.
Far from diluting the competition pool, the new teams in the expanded AFC Champions League showed they can match up against the tournament's best.
Ahead of the start of West Zone action in AFC Champions League 2021, we look at the five major talkings points from Asia's premier club competition.