Francesco Totti converted a penalty deep into stoppage time to send Roma through to the Coppa Italia semifinal with a 2-1 win against Cesena.
Lazio substitutes Sergej Milinkovic-Savic and Ciro Immobile secured a 4-2 win over Genoa in the Italian Cup on Wednesday and a quarterfinal vs. Inter.
Serie B strugglers Cesena stunned Empoli to reach the last-16 of the Coppa Italia following a 2-1 extra-time victory at the Stadio Carlo Castellani.
AC Milan goalkeeper Michael Agazzi has joined Serie B side Cesena.
Cesena cruised to a 4-1 win at fellow Serie B side Catania on Thursday to complete the third round of the Coppa Italia.
Napoli kept their hopes of qualifying for the Champions League next season alive, although they were made to work hard for a 3-2 win over Cesena.
Ambitious Sampdoria were held to an unlikely goalless draw by Cesena on Saturday but used the point to take a share of fourth place in the Serie A table.