Molina and pinch hitter Kolten Wong each stroked an RBI double in the ninth inning, and the St. Louis Cardinals snapped Familia's string of 52 straight saves in rallying to beat the New York Mets 5-4 on Wednesday night.
"A huge boost," Wong said. "We needed this."
Yoenis Cespedes hit a go-ahead homer off Adam Wainwright to cap a three-run comeback in the seventh that gave the Mets a 4-3 lead. But then Familia, who hadn't blown a regular-season save opportunity since July 30, 2015, finally faltered.
Molina was thrown out at third by Familia (2-2) on pinch hitter Jeremy Hazelbaker's comebacker. But Hazelbaker stole second, then he scored when Wong lined a double just inside the left-field line.
"That was probably one of the top, top things I've experienced in a while," said Wong, who lost his everyday job at second base this season and got demoted to the minors last month. "To see some kind of light at the end of the tunnel was definitely something I needed and something that I've been wanting for a long, long time."
"They made good contact on my sinker, and I walked a guy and Molina came and jumped on the first pitch, and that's it," said Familia, who was charged with three blown saves in last year's World Series loss to the Kansas City Royals.
Including a split of Tuesday's doubleheader, St. Louis took two of three from the Mets in a matchup of National League wild-card contenders.
Logan Verrett pitched seven efficient innings, and slumping Neil Walker went 3-for-3 with a base on balls for the third-place Mets, who dropped 5½ games behind the NL East-leading Washington Nationals.
"This is a really tough one to take," said Mets manager Terry Collins.
Wainwright, who entered 3-0 in July with a major league-low 0.93 ERA, nursed that lead until the seventh after repeatedly pitching out of trouble. He nearly did so again after striking out Curtis Granderson and Asdrubal Cabrera with runners at the corners.
But then Travis d'Arnaud scored on a wild pitch, and Cespedes, who fouled off three full-count offerings, socked a two-run home run off the facing of the second deck in left center.
The homer came on the 117th and final pitch from the 34-year-old Wainwright, who had not allowed a home run in just more than 66 innings, since Washington's Ryan Zimmerman connected on May 28. That was the longest such streak in the majors this season.
"It was almost heartbreaking. For a moment, it was. I was at my lowest of lows this season," Wainwright said. "It was almost really bad, but the team saved me tonight."
Because of Tuesday's doubleheader, St. Louis needs a fill-in starter on Saturday night in Miami. But Cardinals manager Mike Matheny would not say whether the team was leaning toward promoting RHP Alex Reyes to make his major league debut. The 21-year-old Reyes, one of baseball's premier prospects, was removed from his Triple-A outing after three innings on Tuesday -- perhaps to keep him available for Saturday. Left-handed reliever Tyler Lyons, who made 20 major league starts from 2013-15, also could be a candidate. "We're not ruling out anything at this point," Matheny said.
Cardinals hitters were kept in the ballpark after the club homered in 17 consecutive games -- its longest streak since a team-record run of 19 in 2006.
Cardinals: 1B-OF Brandon Moss (sprained left ankle) is scheduled to begin a rehab assignment on Thursday at Double-A Springfield, with All-Star INF Matt Carpenter (strained right oblique) not far behind. But neither has a defined timetable to return, Matheny said.
Mets: 3B Jose Reyes received an injection and treatment for the rib cage strain on his left side. He is likely to be sidelined until at least Friday, Collins said, and Wilmer Flores will continue to fill in.
Mets: RHP Jacob deGrom (6-5, 2.73 ERA) looks to rebound from his worst start of the season on Thursday afternoon against Colorado Rockies LHP Tyler Anderson (3-3, 3.56) in the opener of a four-game series.
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