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Johan Santana will face off against Cole Hamels on Friday night in Philadelphia.

WEEKEND PREVIEW

By David Bearman, ESPN Research

This weekend's slate of games has a young-versus-old feel to it. On Friday, you can see a couple of 24-year-olds take the hill in Cole Hamels (versus the Mets) and Francisco Liriano (versus the Indians). Saturday will feature 22-year-old rookie Johnny Cueto (versus the Brewers) making his fourth start, and Sunday, 22-year-old rookie Jair Jurrjens (versus the Dodgers) will take the hill for the Braves.

SUNDAY NIGHT BASEBALL

• Mets at Phillies, 8:05 p.m. ET, ESPN

On the flip side, the weekend will also feature 42-year-old Greg Maddux (versus the Diamondbacks) going for career win No. 350, 42-year-old Tom Glavine (versus the Dodgers) continuing his remarkable run of never going on the disabled list in his 22-season career and 44-year-old Randy Johnson (versus the Padres) making his second start of the 2008 season.

If you just want a good old-fashioned pitching matchup, don't miss Chris Young versus Dan Haren Friday night in the desert. And on Sunday Night Baseball on ESPN, the Mets and Phillies will wrap up their second series of the season with Mike Pelfrey facing Adam Eaton.

Friday

• Mets (Johan Santana) at Phillies (Cole Hamels), 7:05 p.m. ET
Santana, who allowed three home runs in his latest start for the Mets, will make his first career start at the bandbox called Citizens Bank Park. Dating back to last season, Hamels is 3-1 with an 0.77 ERA in his past five starts.

• Dodgers (Derek Lowe) at Braves (Tom Glavine), 7:35 p.m. ET
Glavine, who left his last start in the first inning with an injured left hamstring, is scheduled to start and avoid going on the disabled list for the first time in his career. An old friend will be in the house as Andruw Jones will return to face his former team. Jones hit 368 home runs and won 10 Gold Gloves in 12 seasons with Atlanta before leaving this past offseason for the bright lights of Los Angeles.

• Indians (Cliff Lee) at Twins (Francisco Liriano), 8:10 p.m. ET
Lee, who had a 9.97 ERA in seven appearances after the 2007 All-Star break, is 2-0 with a 0.61 ERA to start 2008. It will also be the second start in the return of Liriano, who allowed four runs in 4 2/3 innings pitched in his first start.

• Padres (Greg Maddux) at Diamondbacks (Dan Haren), 9:40 p.m. ET
Maddux will try to become the ninth pitcher in major league history to win 350 career games, but he'll have to beat the team he has had the least success against. Of his 349 career wins, only two have come against the Diamondbacks. Maddux is 2-10 with a 4.88 ERA in 18 career starts versus Arizona, but he did win his last start against the D-backs last September.

• Complete list of pitching probables for Friday's games

Saturday

• Brewers (Jeff Suppan) at Reds (Johnny Cueto), 1:10 p.m. ET
After allowing just three earned runs in 13 1/3 innings in his first two major league starts, Cueto had his first tough outing in his third start, allowing five earned runs on five hits in six innings. This is a rematch of the April 8 game in which Cueto held the Brewers to two runs over 6 1/3 innings. Suppan, however, was even better that day, holding the Reds to one run over seven innings.

• Padres (Chris Young) at Diamondbacks (Edgar Gonzalez), 8:10 p.m. ET
Young went 9-8 with a respectable 3.12 ERA last season. His only major problem? The Diamondbacks. Young went 0-3 with a 7.32 ERA against Arizona, allowing 17 runs (16 earned) and 11 walks over 19 2/3 innings. Oddly, he allowed one earned run in eight innings over two starts against the D-backs in 2006, with 11 strikeouts and no walks.

• Complete list of pitching probables for Saturday's games

Sunday

• Dodgers (Hiroki Kuroda) at Braves (Jair Jurrjens), 1:35 p.m. ET
Two pitchers relatively new to the majors will square off in this game. Kuroda will make his fourth big league start, having allowed six earned runs over 18 2/3 innings (2.89 ERA) in his first three starts. He'll be opposed by Jurrjens, who will make his 11th major league start. He has never faced the Dodgers.

• Yankees (Andy Pettitte) at Orioles (Steve Trachsel), 1:35 p.m. ET
Pettitte will look to continue his domination of the Orioles, a team he has a 22-6 record against in his career.

BEST CAREER RECORDS BY ACTIVE PITCHERS VERSUS ONE TEAM (MINIMUM 20 DECISIONS)
Pitcher	Opponent	W-L	Winning percentage
Roy Oswalt	Reds	19-1	.950
Tim Wakefield	Rays	19-3	.864
Jamie Moyer	Orioles	18-4	.818
Roy Halladay	Orioles	16-4	.800
Andy Pettitte	Orioles	22-6	.786

• Padres (Randy Wolf) at Diamondbacks (Randy Johnson), 4:10 p.m. ET
Johnson will take the hill for the second time this season. The veteran left-hander did not get a decision in his 2008 debut against the Giants last Monday, but he did have seven strikeouts in five innings. In his career, Johnson has dominated San Diego, going 14-4 with a 2.34 ERA in 23 appearances.

• Complete list of pitching probables for Sunday's games

Past Baseball Tonight Clubhouses: April 16 | April 15 | April 14 | April 13 | April 10 | April 9

NEWS AND NOTES

• Manny Ramirez hit the 494th and 495th homers of his career in the Red Sox's 7-5 win over the Yankees on Thursday. Ramirez is now in 24th place on the career home runs list.

• John Smoltz earned the win in the Braves' 8-0 victory over the Marlins on Thursday, marking the first time in his 21-year career that he has won his first three starts of the season. And it's the third time that Smoltz has begun a season 3-0 or better. (He started 5-0 with one no-decision in 1999, and he started 4-0 with two no decisions in 1998.)