Jed Jacobsohn/Getty Images

The Cubs have had no success against Randy Johnson, who pitches Sunday against Carlos Zambrano.

WEEKEND PREVIEW

By Mark Simon, ESPN Research

The playoff rematch between the Diamondbacks and Cubs is among the most intriguing matchups of the weekend. The Cubs have been sputtering a bit, and now they'll run into the best pitching staff in the National League. Derrek Lee has struggled in May throughout his career, and he's off to a slow start this month -- just like the rest of his team. He'll try to get back on track, but it won't be easy, having to go against Dan Haren and Randy Johnson in this series.

SUNDAY NIGHT BASEBALL

• Red Sox at Twins, 8:05 p.m. ET, ESPN

Johnson may not seem that tough an opponent anymore, but don't tell the Cubs that. He's 12-0 all-time against them, and both Lee and Aramis Ramirez have struggled mightily just to make contact against the Big Unit.

It could be a good weekend to be one of baseball's old men, as Greg Maddux will go for his 350th career win again on Saturday against the Rockies. Jamie Moyer, who defeated D-Backs young gun Max Scherzer this week, takes on another one of baseball's hot young pitchers in San Francisco's Tim Lincecum. Ken Griffey will continue his run at career homer No. 600; he currently stands at 597. Problem is, he'll be at Shea Stadium, where his career batting average is .198.

Friday

• Blue Jays (Roy Halladay) at Indians (C.C. Sabathia), 7:05 p.m. ET
Two aces surprisingly owning losing records go up against each other. On the bright side for each pitcher is they've had success against the opposition. Roy Halladay is 5-0 in his career against the Indians, tied with current Indians pitcher Paul Byrd for the best record against the Indians among active pitchers. C.C. Sabathia is 6-3 against the Blue Jays, who are only hitting .213 against him.

• Diamondbacks (Dan Haren) at Cubs (Ted Lilly), 2:20 p.m. ET
A lot has happened to Dan Haren since his last start against the Cubs. That appearance was a disaster, though what followed has been pretty good. Haren's last game against the Cubs was June 10, 2004, and he allowed a career-worst 10 runs in 3 2/3 innings at Wrigley Field. Since then, he's 50-37. Meanwhile, Ted Lilly is 2-1 with a 2.84 ERA in his last three starts, a significant improvement from the 0-3 record and 9.16 ERA from his first four starts.

• Rockies (Aaron Cook) at Padres (Jake Peavy), 10:05 p.m. ET
It isn't often that an one of Jake Peavy's opponents is pitching better than he is, but that'll be the case tonight. Rockies starter Aaron Cook is 5-0 with a 2.02 ERA in his last six starts, and he hasn't allowed more than two runs in five of those starts.

• Complete list of pitching probables for Friday's games

Saturday

• Angels (Joe Saunders) at Rays (Scott Kazmir), 7 p.m. ET
The Angels have survived John Lackey's absence and Jered Weaver's inconsistency, thanks to Saturday's starter Joe Saunders and Sunday's pitcher Ervin Santana. They're a combined 12-0 this season. The Angels other starters enter the weekend 7-10. Saunders, by the way, is 21-8 in his career. Among active pitchers with 20 or more wins, his .724 winning percentage ranks second-best to Chien-Ming Wang's .732.

• Phillies (Jamie Moyer) at Giants (Tim Lincecum), 4:05 p.m. ET
For the second consecutive start, Jamie Moyer will be facing a hard-throwing, young right-hander who is more than 20 years his junior (he beat Diamondbacks starter Max Scherzer in his last start). A humorous note: Moyer's fastest fastball this season was clocked at 86 mph. Tim Lincecum has been clocked throwing changeups at that speed this season. Lincecum's average changeup comes to the plate at 82 mph. That's two mph faster than your average Moyer fastball.

• Rockies (Ubaldo Jimenez) at Padres (Greg Maddux), 10:05 p.m. ET
Greg Maddux takes his fifth shot at win No. 350. He's 0-3 with a 5.54 ERA in his four tries so far. According to the Elias Sports Bureau, among pitchers who have won 350 games, only one pitcher has needed five tries or more to go from 349 wins to 350. That would be Hall of Famer Kid Nichols, all the way back in 1904.

• Complete list of pitching probables for Saturday's games

Sunday

• Angels (Ervin Santana) at Rays (Andy Sonnanstine), 1:40 p.m. ET
Ervin Santana entered this season 10-21 on the road in his career. This season, he is a perfect 4-0 away from home. Rays starter Andy Sonnanstine has won four straight starts, posting a 2.45 ERA over that stretch. The only Rays pitcher to win five straight starts is Scott Kazmir (5) in 2006. Three other Rays pitchers have won four straight starts and failed to win in their fifth attempt. Another win for Sonnanstine would give him six, matching his total from last season, when he made 22 starts.

• Atlhetics (Rich Harden) at Rangers (Sidney Ponson), 3:05 p.m. ET
Rich Harden is scheduled to make his first start since April 2. He's 5-2 against the Rangers. The five wins against Texas ties for his most against any team with the Mariners and Angels. Meanwhile, the Sidney Ponson reclamation project continues. He's allowed one earned run in each of his first three starts this season and may be headed to his first sub-5.00 ERA season since 2003.

• Diamondbacks (Randy Johnson) at Cubs (Carlos Zambrano), 1:07 p.m. ET
Randy Johnson hasn't faced the Cubs since 2004, and they're thankful for that. He's 12-0 with a 1.98 ERA all-time against them. Johnson has amazing numbers against two of the Cubs best hitters: Derrek Lee and Aramis Ramirez are a combined 7-for-39 with 25 strikeouts in their careers against Johnson. This may be a game in which one run will be enough. Carlos Zambrano has been unhittable lately, going 4-0 with a 1.02 ERA in his last four starts.

• Complete list of pitching probables for Sunday's games

Past Baseball Tonight Clubhouses: May 7 | May 6 | May 5 | May 4 | May 1 | April 30