Winless Tottenham Hotspur host Everton in the Premier League, and you can follow all the updates live on ESPN.
De Zerbi's side are still searching for their first league win of the season, after picking up a solitary point from their opening three fixtures.
Everton, meanwhile, are unbeaten so far but have drawn two of their first three games.
Spurs spent nearly £400 million overhauling their squad this summer following their near-relegation last season. However, their new signings are yet to hit the ground running.
The north London side were hammered 3-0 by Brentford in their opening game of the season before losing 2-0 to Newcastle in their home bow. The goalless draw against Nottingham Forest saw them earn their first point of the season, but they are yet to score a goal this campaign.
Everton's transfer activity has been in sharp contrast to Spurs, with the Merseyside club's lack of reinforcements in the summer drawing the ire of the fanbase.
The club sold talisman Iliman Ndiaye to Manchester City on deadline day, while signing Ainsley Maitland-Niles and Jack Grealish.
Maitland-Niles marked his Everton debut in style with a stunning injury-time goal to secure a point against Manchester United last weekend.