Man United made 11 changes for their Carabao Cup tie vs. West Ham, but the Red Devils would miss the production of their regulars in a sorry defeat.
Tottenham Hotspur surrendered an early 2-0 lead at Wolverhampton Wanderers but eventually won 3-2 on penalties in the Carabao Cup.
Man City will face West Ham in the fourth round of the Carabao Cup, while Arsenal welcome Leeds United.
A much-changed Chelsea side crept into the fourth round of the League Cup as they beat Aston Villa 4-3 on penalties.
Arsenal beat third-tier AFC Wimbledon in the Carabao Cup on Wednesday night, with Alexandre Lacazette scoring once and setting up the second.
Manchester United have been knocked out in the third round of Carabao Cup after a 1-0 defeat to West Ham United at Old Trafford on Wednesday.
Manchester City recovered from a goal down against Wycombe to win 6-1 at the Etihad Stadium and look for a fifth consecutive Carabao Cup win.
Takumi Minamino scored twice in a Liverpool win over Norwich City in the Carabao Cup third round on Tuesday night.
Manchester City's Carabao Cup defence will start vs. Wycombe while Manchester United will face West Ham in the third round of the competition.
Mikel Arteta's Arsenal made short work of West Bromwich Albion in the second round of the Carabao Cup at the Hawthorns on Wednesday night.
Norwich City thumped second-tier Bournemouth 6-0 in the Carabao Cup second round on Tuesday, with U.S. international Josh Sargent scoring twice.
As the Europa Conference League trophy is unveiled, here's how it rates among the silverware that European clubs will be competing for next season.
Man City's latest Carabao Cup crown came with yet more innovation. PLUS: Barcelona get Griezmann's best, and Juve's top-four finish is under threat.