Celtic welcome Beşiktaş to Glasgow as Martin O'Neill's side look to get their first Europa League points on the board, and you can follow all of the action with ESPN.
The Scottish champions have lost all three of their European fixtures so far, leaving them 35th in the 36-team table heading into this one.
O'Neill certainly knows his team are running out of opportunities to revive their league phase campaign.
A 3-1 home defeat to Ferencváros on matchday one was followed by a 4-1 thrashing at Benfica before Celtic suffered another setback at Parkhead, losing 2-1 to Spanish side Celta Vigo.
Things have hardly been plain sailing domestically, either. Celtic were beaten 2-0 by Falkirk on Sunday, having previously dropped points in a 2-2 home draw with Dundee United. Nonetheless, the Hoops remain top of the Scottish Premiership.
Beşiktaş, meanwhile, arrive in Glasgow in a considerably healthier position in Europe. Vincenzo Italiano's side are unbeaten in the league phase, sitting eighth with seven points from their opening three matches.
The Turkish club began with a statement 4-1 victory over Marseille, followed it up with an entertaining 3-2 win away at Hoffenheim and most recently drew 2-2 with Crystal Palace.
They'll be looking to forget a 2-2 league draw at the weekend, though, where they squandered a two-goal advantage against Kasımpaşa. Leandro Trossard opened the scoring in the 28th minute before Dušan Vlahović doubled the advantage shortly after half-time, but an 87th-minute equaliser denied them the win.