| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
C.J. Stroud |
1. C.J. Stroud, QB | HOU | W 44-22 at LAC | 21 | 35 | 384 | 5 | 1 | 1 | 0 | 125.5 |
| 2. Jordan Love, QB | GB | W 45-27 at NE | 23 | 29 | 372 | 3 | 0 | 3 | 0 | 153.2 | |
| 3. Dak Prescott, QB | DAL | W 27-23 at IND | 21 | 34 | 335 | 2 | 0 | 3 | 1 | 114.2 | |
| 4. Drake Maye, QB | NE | L 45-27 vs. GB | 21 | 38 | 299 | 3 | 3 | 4 | 0 | 74.4 | |
| 5. Shedeur Sanders, QB | CLE | L 23-22 at NO | 19 | 31 | 297 | 2 | 0 | 5 | 0 | 114.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
James Cook III |
1. James Cook III, RB | BUF | W 23-6 at MIN | 31 | 107 | 3.5 | 1 | 11 | 0 | |
| 2. Kenneth Walker III, RB | KC | W 35-12 vs. NYJ | 18 | 102 | 5.7 | 1 | 12 | 0 | ||
| 3. Javonte Williams, RB | DAL | W 27-23 at IND | 20 | 101 | 5.1 | 1 | 15 | 0 | ||
| 4. Bijan Robinson, RB | ATL | L 34-17 vs. CIN | 19 | 100 | 5.3 | 1 | 21 | 0 | ||
| 5. Bucky Irving, RB | TB | L 27-24 at CHI | 20 | 97 | 4.9 | 2 | 25 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
CeeDee Lamb |
1. CeeDee Lamb, WR | DAL | W 27-23 at IND | 10 | 195 | 19.5 | 1 | 48 | 1 | |
| 2. Christian Watson, WR | GB | W 45-27 at NE | 7 | 171 | 24.4 | 1 | 43 | 0 | ||
| 3. Matthew Golden, WR | GB | W 45-27 at NE | 10 | 164 | 16.4 | 1 | 49 | 0 | ||
| 4. Ja'Marr Chase, WR | CIN | W 34-17 at ATL | 10 | 155 | 15.5 | 1 | 47 | 0 | ||
| 5. Puka Nacua, WR | LAR | W 20-13 at WSH | 14 | 150 | 10.7 | 1 | 21 | 1 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Nakobe Dean |
1. Nakobe Dean, LB | LV | L 38-17 at SF | 7 | 12 | 19 | 0.0 | 0 | 0 | 0 |
| 2. Hunter Wohler, S | IND | L 27-23 vs. DAL | 6 | 10 | 16 | 0.0 | 0 | 0 | 0 | |
| 3. Carson Schwesinger, LB | CLE | L 23-22 at NO | 10 | 5 | 15 | 2.0 | 1 | 0 | 0 | |
| 4. Frankie Luvu, LB | WSH | L 20-13 vs. LAR | 7 | 8 | 15 | 1.0 | 0 | 0 | 0 | |
| 5. Jessie Bates III, S | ATL | L 34-17 vs. CIN | 11 | 3 | 14 | 0.0 | 0 | 0 | 0 | |