| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Justin Herbert |
1. Justin Herbert, QB | LAC | W 28-24 at MIN | 40 | 47 | 405 | 3 | 0 | 1 | 0 | 123.8 |
| 2. Kirk Cousins, QB | MIN | L 28-24 vs. LAC | 32 | 50 | 367 | 3 | 1 | 4 | 0 | 97.7 | |
| 3. Andy Dalton, QB | CAR | L 37-27 at SEA | 34 | 58 | 361 | 2 | 0 | 3 | 0 | 88.4 | |
| 4. Jimmy Garoppolo, QB | LV | L 23-18 vs. PIT | 28 | 44 | 324 | 2 | 3 | 4 | 0 | 72.5 | |
| 5. Brock Purdy, QB | SF | W 30-12 vs. NYG | 25 | 37 | 310 | 2 | 0 | 2 | 0 | 111.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
De'Von Achane |
1. De'Von Achane, RB | MIA | W 70-20 vs. DEN | 18 | 203 | 11.3 | 2 | 67 | 0 | |
| 2. D'Andre Swift, RB | PHI | W 25-11 at TB | 16 | 130 | 8.1 | 0 | 29 | 0 | ||
| 3. Tony Pollard, RB | DAL | L 28-16 at ARI | 23 | 122 | 5.3 | 0 | 31 | 0 | ||
| 4. Zack Moss, RB | IND | W 22-19 at BAL | 30 | 122 | 4.1 | 0 | 24 | 0 | ||
| 5. Lamar Jackson, QB | BAL | L 22-19 vs. IND | 14 | 101 | 7.2 | 2 | 16 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Keenan Allen |
1. Keenan Allen, WR | LAC | W 28-24 at MIN | 18 | 215 | 11.9 | 0 | 25 | 0 | |
| 2. Davante Adams, WR | LV | L 23-18 vs. PIT | 13 | 172 | 13.2 | 2 | 32 | 0 | ||
| 3. Tyreek Hill, WR | MIA | W 70-20 vs. DEN | 9 | 157 | 17.4 | 1 | 54 | 0 | ||
| 4. Justin Jefferson, WR | MIN | L 28-24 vs. LAC | 7 | 149 | 21.3 | 1 | 52 | 0 | ||
| 5. Adam Thielen, WR | CAR | L 37-27 at SEA | 11 | 145 | 13.2 | 1 | 25 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
T.J. Edwards |
1. T.J. Edwards, LB | CHI | L 41-10 at KC | 6 | 11 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Zaire Franklin, LB | IND | W 22-19 at BAL | 11 | 4 | 15 | 1.0 | 0 | 0 | 0 | |
| 3. Foyesade Oluokun, LB | JAX | L 37-17 vs. HOU | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Kyzir White, LB | ARI | W 28-16 vs. DAL | 8 | 6 | 14 | 0.0 | 0 | 1 | 0 | |
| 5. Delarrin Turner-Yell, S | DEN | L 70-20 at MIA | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |