| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | W 33-30 vs. IND | 32 | 47 | 382 | 3 | 0 | 2 | 0 | 114.0 |
| 2. C.J. Stroud, QB | HOU | L 20-6 vs. CIN | 30 | 55 | 353 | 0 | 0 | 4 | 0 | 74.3 | |
| 3. Matthew Stafford, QB | LAR | W 28-6 vs. NYG | 22 | 31 | 327 | 4 | 1 | 1 | 0 | 131.3 | |
| 4. Jared Goff, QB | DET | L 41-31 at BUF | 26 | 38 | 327 | 4 | 0 | 4 | 0 | 130.0 | |
| 5. Bo Nix, QB | DEN | W 20-13 vs. JAX | 22 | 31 | 288 | 1 | 1 | 0 | 0 | 97.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
James Cook III |
1. James Cook III, RB | BUF | W 41-31 vs. DET | 21 | 135 | 6.4 | 1 | 35 | 0 | |
| 2. Kenneth Walker III, RB | KC | W 33-30 vs. IND | 24 | 117 | 4.9 | 0 | 19 | 0 | ||
| 3. Aaron Jones Sr., RB | MIN | W 9-3 at CHI | 23 | 105 | 4.6 | 0 | 20 | 0 | ||
| 4. Omarion Hampton, RB | LAC | L 26-14 vs. LV | 23 | 94 | 4.1 | 1 | 17 | 1 | ||
| 5. Emanuel Wilson, RB | SEA | W 31-7 at ARI | 21 | 92 | 4.4 | 0 | 18 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Davante Adams |
1. Davante Adams, WR | LAR | W 28-6 vs. NYG | 8 | 195 | 24.4 | 2 | 64 | 0 | |
| 2. Jaxon Smith-Njigba, WR | SEA | W 31-7 at ARI | 9 | 155 | 17.2 | 3 | 82 | 0 | ||
| 3. CeeDee Lamb, WR | DAL | W 37-20 vs. WSH | 8 | 153 | 19.1 | 2 | 38 | 0 | ||
| 4. Amon-Ra St. Brown, WR | DET | L 41-31 at BUF | 9 | 142 | 15.8 | 2 | 34 | 0 | ||
| 5. Dalton Schultz, TE | HOU | L 20-6 vs. CIN | 12 | 140 | 11.7 | 0 | 35 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Akeem Davis-Gaither |
1. Akeem Davis-Gaither, LB | IND | L 33-30 at KC | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Kyle Hamilton, S | BAL | L 24-17 vs. NO | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Nick Bolton, LB | KC | W 33-30 vs. IND | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Josiah Trotter, LB | TB | L 23-19 vs. CLE | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Ji'Ayir Brown, S | SF | W 35-13 vs. MIA | 4 | 9 | 13 | 0.0 | 0 | 0 | 0 | |