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Predicting NFL Week 13 upsets and fantasy football sleepers, plus buzz and notes around the league

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Why the Colts are poised to surge into the playoffs (1:08)

Marcus Spears explains why he expects the Colts to finish the season strong and make the postseason. (1:08)

It's Week 13 of the 2021 NFL season, and we asked our insiders Dan Graziano and Jeremy Fowler for insight on the biggest news and for their picks on games and players to watch this weekend.

This week's slate concludes with a massive Patriots-Bills Monday Night Football matchup in Buffalo (8:15 p.m. ET, ESPN) that has big implications for both the AFC East race and the overall AFC playoff picture. Can Mac Jones outduel Josh Allen to stay perfect on the road? Graziano and Fowler take a closer look at the matchup with the biggest keys to the game -- and who will win. Plus, they pick out their top upset watches for Week 13.

But they won't stop there. Graziano and Fowler also pick teams currently sitting outside the top seven that will end up making the playoffs. They also look at coaches and players who have a lot to prove down the regular season's final stretch. And for fantasy managers looking to make all the right moves, our insiders name must-start sleepers. They get into all of it, emptying their notebooks with everything they've heard this week, including the latest on Amari Cooper's availability for Thursday and injury updates for Russell Wilson, Deebo Samuel, Dalvin Cook and D'Andre Swift.

Let's get started with the upset picks of the week, but you can also jump to other big questions.

Jump to:
Keys to NE-BUF | Playoff sleepers
Most to prove | Upsets | Fantasy starts
Notebook: Everything we're hearing

What's the biggest key to Monday night's pivotal Patriots-Bills showdown -- and who will win?