NFL Week 6 betting: Odds, lines and totals for every game

Brock Purdy and the undefeated 49ers are big favorites in their Monday night matchup with the Commanders. Darren Yamashita/Imagn Images

Week 6 gets underway with the Seattle Seahawks visiting the Denver Broncos on "Thursday Night Football." The defending champions are early 3-point favorites. It is one of seven games with a spread of three points or less.

Kicking off Sunday's play is an AFC South matchup between the Houston Texans and Jacksonville Jaguars in London (9:30 a.m. ET start).

The Los Angeles Rams are the biggest favorite of the week, laying 12.5 points at home versus the Arizona Cardinals. The total for the game is 52.5, one of four games with a total over 50.

The Dallas Cowboys, coming off a loss to the previously winless Tampa Bay Buccaneers, head to Lambeau Field to take on the Green Bay Packers on Sunday night, and the San Francisco 49ers host the Washington Commanders on "Monday Night Football" (8:15 p.m. ET on ESPN/ABC) to close out the week.

The Cincinnati Bengals, Detroit Lions, Miami Dolphins and Minnesota Vikings are on bye. Here's a look at the odds for every game this week.

Note: Odds by DraftKings and subject to change. All times Eastern.

Jump to:
SEA-DEN | HOU-JAX | CHI-ATL | TEN-IND
CAR-PHI | NYJ-NE | BAL-CLE | NO-NYG
PIT-TB | ARI-LAR | BUF-LV | LAC-KC
DAL-GB | WSH-SF


Seattle Seahawks -3 vs. Denver Broncos
Thursday, 8:15 p.m., Prime Video


Moneyline: Seahawks (-148); Broncos (+124)
Total: 41.5; Opened: 43.5
FPI favorite: Seahawks by 1.4 with a 55% probability to win the game outright


Houston Texans vs. Jacksonville Jaguars -3
Sunday, 9:30 a.m., NFL Network


Moneyline: Jaguars (-148); Texans (+124)
Total: 43.5; Opened: 41.5
FPI favorite: Jaguars by 3.6 with a 64% probability to win the game outright


Chicago Bears -3 vs. Atlanta Falcons
Sunday, 1 p.m., Fox


Moneyline: Bears (-175); Falcons (+145)
Total: 47.5; Opened: 47.5
FPI favorite: Bears by 5.6 with a 70% probability to win the game outright


Check out the latest Super Bowl odds and major NFL awards futures.


Tennessee Titans vs. Indianapolis Colts -7
Sunday, 1 p.m., Fox


Moneyline: Titans (+260); Colts (-325)
Total: 44.5; Opened: 48.5
FPI favorite: Colts by 5.4 with a 70% probability to win the game outright


Carolina Panthers vs. Philadelphia Eagles -1.5
Sunday, 1 p.m., CBS


Moneyline: Panthers (-102); Eagles (-118)
Total: 42.5; Opened: 43.5
FPI favorite: Panthers by 0.2 with a 50.5% probability to win the game outright


New York Jets vs. New England Patriots -7
Sunday, 1 p.m., CBS


Moneyline: Jets (+260); Patriots (-325)
Total: 44.5; Opened: 42.5
FPI favorite: Patriots by 6.7 with a 74% probability to win the game outright


Baltimore Ravens -4.5 vs. Cleveland Browns
Sunday, 1 p.m., Fox


Moneyline: Ravens (-230); Browns (+190)
Total: 40.5; Opened: 44.5
FPI favorite: Ravens by 6.5 with a 73% probability to win the game outright


New Orleans Saints -1.5 vs. New York Giants
Sunday, 1 p.m., Fox


Moneyline: Saints (-115); Giants (-105)
Total: 45.5; Opened: 45.5
FPI favorite: Saints by 4.5 with a 67% probability to win the game outright


Pittsburgh Steelers -3 vs. Tampa Bay Buccaneers
Sunday, 1 p.m., CBS


Moneyline: Steelers (-155); Buccaneers (+130)
Total: 40.5; Opened: 45.5
FPI favorite: Steelers by 3 with a 61% probability to win the game outright


Arizona Cardinals vs. Los Angeles Rams -12.5
Sunday, 4:05 p.m., Fox


Moneyline: Cardinals (+490); Rams (-675)
Total: 52.5; Opened: 46.5
FPI favorite: Rams by 11.3 with a 86% probability to win the game outright


Buffalo Bills -6 vs. Las Vegas Raiders
Sunday, 4:25 p.m., CBS


Moneyline: Bills (-258); Raiders (+210)
Total: 52.5; Opened: 47.5
FPI favorite: Bills by 3.7 with a 64% probability to win the game outright


Los Angeles Chargers vs. Kansas City Chiefs -8.5
Sunday, 4:25 p.m., CBS


Moneyline: Chargers (+285); Chiefs (-360)
Total: 42.5; Opened: 46.5
FPI favorite: Chiefs by 6.1 with a 72% probability to win the game outright


Dallas Cowboys vs. Green Bay Packers -1.5
Sunday, 8:20 p.m., NBC


Moneyline: Cowboys (-105); Packers (-115)
Total: 52.5; Opened: 51.5
FPI favorite: Cowboys by 3.4 with a 63% probability to win the game outright


Washington Commanders vs. San Francisco 49ers -7.5
Monday, 8:15 p.m., ESPN, ABC


Moneyline: Commanders (+340); 49ers (-440)
Total: 50.5; Opened: 50.5
FPI favorite: 49ers by 11.2 with a 86% probability to win the game outright