| 2021 Cy Young Predictor - AL | |||||||||||||
| RK | PLAYER | TEAM | CYP | G | GS | IP | ER | K | SV | SHO | W-L | ERA | VB |
| 1 | Liam Hendriks | CHW | 177.9 | 69 | 0 | 71.0 | 20 | 113 | 38 | 0 | 8-3 | 2.54 | 12 |
| 2 | Raisel Iglesias | LAA | 144.5 | 65 | 0 | 70.0 | 20 | 103 | 34 | 0 | 7-5 | 2.57 | 0 |
| 3 | Gerrit Cole | NYY | 137.0 | 30 | 30 | 181.1 | 65 | 243 | 0 | 1 | 16-8 | 3.23 | 0 |
| 4 | Carlos Rodon | CHW | 135.1 | 24 | 24 | 132.2 | 35 | 185 | 0 | 1 | 13-5 | 2.37 | 12 |
| 5 | Robbie Ray | TOR | 131.1 | 32 | 32 | 193.1 | 61 | 248 | 0 | 0 | 13-7 | 2.84 | 0 |
| 6 | Lance McCullers Jr. | HOU | 128.6 | 28 | 28 | 162.1 | 57 | 185 | 0 | 0 | 13-5 | 3.16 | 12 |
| 7 | Ryan Pressly | HOU | 127.3 | 64 | 0 | 64.0 | 16 | 81 | 26 | 0 | 5-3 | 2.25 | 12 |
| 8 | Jordan Romano | TOR | 124.6 | 62 | 0 | 63.0 | 15 | 85 | 23 | 0 | 7-1 | 2.14 | 0 |
| 9 | Lance Lynn | CHW | 121.9 | 28 | 28 | 157.0 | 47 | 176 | 0 | 1 | 11-6 | 2.69 | 12 |
| 10 | Aroldis Chapman | NYY | 121.4 | 61 | 0 | 56.1 | 21 | 97 | 30 | 0 | 6-4 | 3.36 | 0 |
| 2021 Cy Young Predictor - NL | |||||||||||||
| RK | PLAYER | TEAM | CYP | G | GS | IP | ER | K | SV | SHO | W-L | ERA | VB |
| 1 | Julio Urias | LAD | 172.4 | 32 | 32 | 185.2 | 61 | 195 | 0 | 0 | 20-3 | 2.96 | 0 |
| 2 | Walker Buehler | LAD | 164.0 | 33 | 33 | 207.2 | 57 | 212 | 0 | 0 | 16-4 | 2.47 | 0 |
| 3 | Max Scherzer | WSH | 152.3 | 30 | 30 | 179.1 | 49 | 236 | 0 | 0 | 15-4 | 2.46 | 0 |
| 4 | Josh Hader | MIL | 150.1 | 60 | 0 | 58.2 | 8 | 102 | 34 | 0 | 4-2 | 1.23 | 12 |
| 5 | Kevin Gausman | SF | 149.6 | 34 | 33 | 192.0 | 60 | 227 | 0 | 0 | 14-6 | 2.81 | 12 |
| 6 | Adam Wainwright | STL | 148.1 | 32 | 32 | 206.1 | 70 | 174 | 0 | 1 | 17-7 | 3.05 | 0 |
| 7 | Mark Melancon | SD | 140.3 | 64 | 0 | 64.2 | 16 | 59 | 39 | 0 | 4-3 | 2.23 | 0 |
| 8 | Kenley Jansen | LAD | 139.5 | 69 | 0 | 69.0 | 17 | 86 | 38 | 0 | 4-4 | 2.22 | 0 |
| 9 | Zack Wheeler | PHI | 139.1 | 32 | 32 | 213.1 | 66 | 247 | 0 | 2 | 14-10 | 2.78 | 0 |
| 10 | Alex Reyes | STL | 138.6 | 70 | 0 | 72.1 | 26 | 95 | 29 | 0 | 10-8 | 3.24 | 0 |