Whom should you start? Whom should you sit? To help you set your fantasy football lineups and avoid starting an offensive player who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their official inactives lists.
Official Sunday inactives should begin coming in approximately 90 minutes before the scheduled kickoff times: around 11:30 a.m. ET for the early games and 2:30 p.m. ET for the late-afternoon games.
Refresh often for the latest information.
Don't forget to check these out: Mike Clay's Playbook | Week 2 Buzz
Week 2 Rankings | Matchup rankings for Week 2
Biggest concerns heading into Week 2
Players with early starts
Zay Flowers, WR, Ravens (hamstring): Flowers was on his way to a monstrous Week 1 performance when he exited due to a hamstring injury that caused him to miss the first two days of practice this week. He did return to the field on Friday, giving him a chance to suit up in Week 2. However, he is officially doubtful to go. If Flowers were to suit up this week, there is added risk that he could once again exit early.
If he sits, Rashod Bateman would be the No. 1 WR option for Lamar Jackson and would bring upside for fantasy, even if the floor is low. Mark Andrews should be started as a TE1. Some streaming options this week include Jalen Coker, Caleb Douglas, Devaughn Vele, plus a sleeper for this week, DeMario Douglas.
Joe Burrow, QB, Bengals (back): Burrow is dealing with back soreness and is listed as questionable but is expected to start. The quarterback stated that it would be "ridiculous" if the injury caused him to miss Week 2. Even in a tough matchup like the Texans, Burrow is a fantasy QB1.
If you want to avoid the matchup, Jaxson Dart and Brock Purdy are realistic options that a fantasy manager could have backing up Burrow. If you're skittish, those two could be started over him. However, for most of you, the choice should be to ride with Burrow.
TreVeyon Henderson, RB, Patriots (ankle): After missing the Patriots' opener due to an ankle injury, Henderson returned to practice this week and says he is "ready to go" for Week 2. Henderson will share work in the backfield with Rhamondre Stevenson. However, he is the more explosive option and therefore brings more fantasy upside.
Henderson can be played over Quinshon Judkins, MarShawn Lloyd, Tony Pollard, J.K. Dobbins, Rico Dowdle, Blake Corum, Kenny Gainwell and Jonathon Brooks.
Jalen Coker, WR, Panthers (ankle): After a huge Week 1 performance, Coker was limited in practice to start the week due to an ankle injury. He was able to log a full practice on Friday and was removed from the injury report, meaning he will play in Week 2. While the Panthers will not often have "scorefests" like they did in Week 1, Coker's usage jumps off the screen. He saw nine targets -- three of the deep variety -- and finished with 138 yards and a touchdown, while narrowly missing a second score.
Coker is a high upside WR3. You can feel comfortable playing him over DK Metcalf, Michael Pittman Jr, Alec Pierce, Marvin Harrison Jr and Chris Godwin Jr.
Michael Pittman Jr., WR, Steelers (foot): Pittman missed practice all week and is questionable for Week 2. His absence would likely lead to another game of high volume for Metcalf (and potentially shadow coverage by Patriots corner Christian Gonzalez).
Pittman is coming off of a disappointing Week 1 and should see a healthy dose of Gonzalez himself if he suits up. He is a recommended sit. Some options you can play over him are Coker, Pierce, and Stefon Diggs.
Alvin Kamara, RB, Saints (knee): Kamara has "moved well" at practice and Kellen Moore has said he should play this week. He is a flex option that brings some PPR upside, but also some risk as we do not know how much work he will see. If he plays, it would be a bit of a thorn in the side of Travis Etienne Jr., who saw nine targets in Week 1.
Players with late starts
Brock Bowers, TE, Raiders (knee): Bowers returned to practice on Friday after having undergone meniscus surgery prior to Week 1. Bowers is doubtful to play in Week 2. Still, if he does get the green light, he should be started -- even if he is limited. If he sits, some replacement options are Schultz, Juwan Johnson and Michael Mayer. Mayer saw a team-high seven targets last week in Bowers' absence.
Ladd McConkey, WR, Chargers (ribs): After leaving Week 1's game early, McConkey didn't practice until Friday. He is questionable but trending towards being available for Week 2. If he were to sit, it would mean more opportunity for Quentin Johnston, who would still fall in the high-risk, high-reward WR3/flex range. If fantasy managers need streamers to fill in, some options are Coker, Douglas, Vele, Dontayvion Wicks and the sleeper Douglas.
Brian Thomas Jr, WR, Jaguars (shoulder): After he had been limited in practice this week, Thomas was elevated to full on Friday and taken off the injury report. He'll face a tough Broncos secondary and could line up against Pat Surtain II. Thomas saw just three targets in Week 1 and, given the matchup, the floor here is low. Starting him this week is likely hoping for a big play. Some options to play instead are Diggs, Coker, Johnston and Jordan Addison.
George Kittle, TE, 49ers (Achilles): Kittle was elevated to full practice after being limited to start the week. This seems like something fantasy managers may have to get used to early on as the veteran is returning from a severe injury. He has been removed from the injury report and will suit up in Week 2. However, he was limited to just 47% of snaps and saw just five targets in Week 1. That said, as time goes on, his usage should gradually increase.
Kaelon Black, RB, 49ers (groin): The rookie back who was added in a bunch of fantasy leagues this week was added to the injury report on Thursday. A late-week add is never a good sign for that week's availability. He was limited on Friday and is questionable for Week 2. While Black was likely not started in many fantasy leagues, this news likely signals that Jordan James will be Christian McCaffrey's Week 2 backup. What it most means for fantasy, however, is more carries for CMC.
Ruled out before Sunday
Nico Collins, WR, Texans (hamstring): Collins missed practice this week due to a hamstring injury and has been ruled out for Week 2. Some streaming options this week include Coker, Douglas, Vele, and Douglas. For the Texans, Kayshon Boutte and Dalton Schultz should see the biggest volume increase. Schultz should be started as a TE1, while Boutte is a big play-reliant flex option.
A.J. Brown, WR, Patriots (ankle): Brown landed on IR due to a high-ankle sprain that reportedly could keep him out for six weeks. Fantasy managers also need to worry about a "ramp up period" when he eventually returns. In the meantime, you need a plan to help you stay afloat without the early-round WR.
Kyler Murray, QB, Vikings (concussion): Murray has been ruled out for Week 2. It's unfortunate timing considering the fantastic matchup here against the Bears. With Murray out, Carson Wentz becomes one of the top streaming options of the week. I would play him over Baker Mayfield, Bryce Young, C.J. Stroud, and Daniel Jones.
Jordan Mason, RB, Vikings (thumb): Mason was placed on IR this week due to a fractured thumb and will miss a minimum of four games. In his absence, Aaron Jones Sr. should handle the bulk of the team's backfield work, placing him in the RB2 range until Mason returns.
Sam Darnold, QB, Seahawks (glute): The Super Bowl champion will not play in Week 2's game against the Cardinals. There is good news here, as the Seahawks did not place him on IR, indicating they think he can return sooner than the mandatory four games. Some streaming replacements for Week 2 are Malik Willis, Tyler Shough and Wentz.
Michael Penix Jr., QB, Falcons (knee): Penix has been ruled out for Week 2. Tua Tagovailoa is doubtful for Week 2 due to the oblique injury that also cost him Week 1. Kevin Stefanski has been non-committal on his starting QB, but the expectation is that Cooper Rush will be under center.
It's very difficult to trust any Falcons player not named Bijan Robinson. Drake London would still fall in WR3 territory but I would rather play Christian Watson, Terry McLaurin, Tetairoa McMillan or Mike Evans. Kyle Pitts Sr., who had only one target in Week 1, is a sit this week.
De'Zhaun Stribling, WR, 49ers (ankle): The rookie suffered a severe ankle injury in Australia that required surgery. He was placed on IR and reportedly could miss as many as 10 weeks. Unfortunately, that means he can be dropped in leagues that do not have IR spots. In his absence, expect Demarcus Robinson to get consistent playing time.
Ja'Kobi Lane, WR, Ravens (wrist): Another rookie receiver who put together an impressive preseason, Lane fractured his wrist and was placed on IR. He will miss at least four games. Bateman should get opportunities as the Ravens' WR2 while the rookie is sidelined.
Chig Okonkwo, TE, Commanders (hamstring): Okonkwo was gaining steam as a sleeper this week, but unfortunately will be out due to a hamstring injury. For those who were planning on streaming him, some other options at tight end include Schultz, Mayer and Juwan Johnson.