| 2021 Cy Young Predictor - AL | |||||||||||||
| RK | PLAYER | TEAM | CYP | G | GS | IP | ER | K | SV | SHO | W-L | ERA | VB |
| 1 | Nathan Eovaldi | BOS | 35.2 | 4 | 4 | 23.2 | 8 | 24 | 0 | 0 | 3-1 | 3.04 | 12 |
| 2 | Eduardo Rodriguez | BOS | 34.4 | 3 | 3 | 16.0 | 6 | 18 | 0 | 0 | 3-0 | 3.38 | 12 |
| 3 | Yusmeiro Petit | OAK | 34.3 | 10 | 0 | 10.2 | 2 | 5 | 0 | 0 | 3-0 | 1.69 | 12 |
| 4 | Danny Duffy | KC | 32.6 | 3 | 3 | 18.0 | 1 | 19 | 0 | 0 | 2-1 | 0.50 | 12 |
| 5 | Matt Barnes | BOS | 30.8 | 8 | 0 | 9.0 | 1 | 16 | 3 | 0 | 1-0 | 1.00 | 12 |
| 6 | Carlos Rodon | CHW | 30.6 | 3 | 3 | 19.0 | 1 | 24 | 0 | 1 | 3-0 | 0.47 | 0 |
| 7 | Sean Manaea | OAK | 30.0 | 4 | 4 | 23.2 | 8 | 22 | 0 | 1 | 2-1 | 3.04 | 12 |
| 8 | Lou Trivino | OAK | 29.5 | 11 | 0 | 13.0 | 2 | 15 | 2 | 0 | 1-0 | 1.38 | 12 |
| 9 | Rafael Montero | SEA | 28.4 | 9 | 0 | 9.1 | 3 | 8 | 3 | 0 | 1-0 | 2.89 | 12 |
| 10 | Kendall Graveman | SEA | 27.9 | 6 | 0 | 7.2 | 0 | 8 | 2 | 0 | 1-0 | 0.00 | 12 |
| 2021 Cy Young Predictor - NL | |||||||||||||
| RK | PLAYER | TEAM | CYP | G | GS | IP | ER | K | SV | SHO | W-L | ERA | VB |
| 1 | Marcus Stroman | NYM | 40.0 | 3 | 3 | 20.0 | 2 | 11 | 0 | 0 | 3-0 | 0.90 | 12 |
| 2 | Julio Urias | LAD | 38.4 | 4 | 4 | 25.2 | 8 | 26 | 0 | 0 | 3-0 | 2.81 | 12 |
| 3 | Corbin Burnes | MIL | 37.9 | 4 | 4 | 24.1 | 1 | 40 | 0 | 0 | 2-1 | 0.37 | 12 |
| 4 | Clayton Kershaw | LAD | 37.7 | 4 | 4 | 24.2 | 6 | 24 | 0 | 0 | 3-1 | 2.19 | 12 |
| 5 | Yimi Garcia | MIA | 37.6 | 10 | 0 | 10.1 | 1 | 10 | 4 | 0 | 2-1 | 0.87 | 12 |
| 6 | Josh Hader | MIL | 35.6 | 6 | 0 | 5.2 | 0 | 11 | 3 | 0 | 2-0 | 0.00 | 12 |
| 7 | Trevor Bauer | LAD | 34.4 | 4 | 4 | 26.0 | 7 | 36 | 0 | 0 | 2-0 | 2.42 | 12 |
| 8 | Trevor Rogers | MIA | 32.8 | 4 | 4 | 22.0 | 4 | 31 | 0 | 0 | 2-1 | 1.64 | 12 |
| 9 | Freddy Peralta | MIL | 32.6 | 4 | 3 | 18.0 | 4 | 31 | 0 | 0 | 2-0 | 2.00 | 12 |
| 10 | Jose Alvarado | PHI | 29.5 | 6 | 0 | 5.2 | 1 | 10 | 1 | 0 | 2-0 | 1.59 | 12 |