| 2021 Cy Young Predictor - AL | |||||||||||||
| RK | PLAYER | TEAM | CYP | G | GS | IP | ER | K | SV | SHO | W-L | ERA | VB |
| 1 | John Means | BAL | 47.7 | 7 | 7 | 46.0 | 7 | 50 | 0 | 1 | 4-0 | 1.37 | 0 |
| 2 | Yusmeiro Petit | OAK | 47.7 | 16 | 0 | 18.1 | 2 | 12 | 1 | 0 | 4-0 | 0.98 | 12 |
| 3 | Emmanuel Clase | CLE | 46.2 | 15 | 0 | 14.1 | 0 | 15 | 6 | 0 | 2-1 | 0.00 | 12 |
| 4 | Aaron Civale | CLE | 46.2 | 6 | 6 | 39.1 | 14 | 28 | 0 | 0 | 4-0 | 3.20 | 12 |
| 5 | Nick Pivetta | BOS | 44.8 | 6 | 6 | 30.2 | 11 | 33 | 0 | 0 | 4-0 | 3.23 | 12 |
| 6 | Gerrit Cole | NYY | 44.3 | 7 | 7 | 44.2 | 8 | 66 | 0 | 0 | 4-1 | 1.61 | 0 |
| 7 | Matt Barnes | BOS | 43.4 | 16 | 0 | 17.0 | 4 | 29 | 7 | 0 | 1-0 | 2.12 | 12 |
| 8 | Shane Bieber | CLE | 43.3 | 7 | 7 | 48.1 | 16 | 77 | 0 | 0 | 3-2 | 2.98 | 12 |
| 9 | Tyler Glasnow | TB | 41.6 | 7 | 7 | 43.2 | 10 | 64 | 0 | 0 | 4-1 | 2.06 | 0 |
| 10 | Eduardo Rodriguez | BOS | 41.1 | 5 | 5 | 28.0 | 13 | 31 | 0 | 0 | 4-0 | 4.18 | 12 |
| 2021 Cy Young Predictor - NL | |||||||||||||
| RK | PLAYER | TEAM | CYP | G | GS | IP | ER | K | SV | SHO | W-L | ERA | VB |
| 1 | Jack Flaherty | STL | 51.1 | 6 | 6 | 34.1 | 13 | 36 | 0 | 0 | 5-0 | 3.41 | 12 |
| 2 | Alex Reyes | STL | 50.4 | 15 | 0 | 15.1 | 0 | 16 | 9 | 0 | 1-0 | 0.00 | 12 |
| 3 | Mark Melancon | SD | 48.0 | 14 | 0 | 15.0 | 1 | 14 | 11 | 0 | 0-0 | 0.60 | 12 |
| 4 | Yu Darvish | SD | 46.0 | 7 | 7 | 43.2 | 11 | 57 | 0 | 0 | 3-1 | 2.27 | 12 |
| 5 | Aaron Nola | PHI | 43.3 | 7 | 7 | 43.2 | 14 | 49 | 0 | 1 | 3-1 | 2.89 | 12 |
| 6 | Zack Wheeler | PHI | 42.6 | 7 | 7 | 47.2 | 15 | 49 | 0 | 1 | 3-2 | 2.83 | 12 |
| 7 | Kevin Gausman | SF | 40.4 | 6 | 6 | 39.2 | 9 | 40 | 0 | 0 | 2-0 | 2.04 | 12 |
| 8 | Alex Wood | SF | 39.6 | 4 | 4 | 23.0 | 5 | 22 | 0 | 0 | 3-0 | 1.96 | 12 |
| 9 | Anthony DeSclafani | SF | 37.8 | 6 | 6 | 36.0 | 8 | 33 | 0 | 1 | 2-1 | 2.00 | 12 |
| 10 | Julio Urias | LAD | 36.4 | 6 | 6 | 37.2 | 12 | 42 | 0 | 0 | 4-0 | 2.87 | 0 |