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| MLB Pitching Leaders | |||||||||||||
| RK | PLAYER | TEAM | OPP | SCORE | IP | H | R | ER | BB | K | PIT | DEC | ESPN* |
| 1 | Dylan Cease | TOR | @ SEA | 2-0 W | 7.0 | 3 | 0 | 0 | 1 | 9 | 102 | W | 79.00 |
| 2 | Jake Bennett | BOS | @ LAA | 5-2 W | 7.2 | 5 | 2 | 2 | 0 | 6 | 92 | W | 67.00 |
| Spencer Arrighetti | HOU | vs TB | 1-3 L | 6.0 | 2 | 1 | 1 | 1 | 4 | 73 | ND | 67.00 | |
| 4 | Trevor Rogers | BAL | @ CIN | 3-0 W | 5.0 | 2 | 0 | 0 | 5 | 4 | 93 | W | 62.00 |
| 5 | Michael King | SD | @ LAD | 3-4 L | 6.0 | 3 | 2 | 2 | 2 | 5 | 75 | ND | 61.00 |
| 6 | Nick Martinez | TB | @ HOU | 3-1 W | 5.1 | 3 | 1 | 1 | 1 | 3 | 85 | ND | 60.00 |
| Andre Pallante | STL | @ CHC | 17-1 W | 5.2 | 5 | 0 | 0 | 1 | 2 | 102 | W | 60.00 | |
| 8 | Ryan Feltner | COL | vs SF | 15-3 W | 6.0 | 6 | 3 | 2 | 0 | 9 | 88 | W | 59.00 |
| 9 | Luis Castillo | SEA | vs TOR | 0-2 L | 6.0 | 5 | 2 | 2 | 1 | 4 | 101 | L | 57.00 |
| 10 | Gerrit Cole | NYY | vs MIN | 5-2 W | 5.0 | 5 | 2 | 2 | 0 | 7 | 88 | W | 56.00 |
| Foster Griffin | WSH | vs PIT | 9-5 W | 5.0 | 4 | 1 | 1 | 1 | 2 | 83 | W | 56.00 | |
| Anthony Kay | CHW | @ CLE | 3-4 L | 4.0 | 1 | 1 | 1 | 2 | 2 | 48 | ND | 56.00 | |
| 13 | Shohei Ohtani | LAD | vs SD | 4-3 W | 6.0 | 7 | 3 | 3 | 2 | 9 | 110 | ND | 53.00 |
| 14 | Grant Holmes | ATL | vs NYM | 5-3 W | 5.0 | 5 | 2 | 1 | 1 | 2 | 82 | W | 52.00 |
| Brady Singer | CIN | vs BAL | 0-3 L | 5.0 | 3 | 3 | 2 | 5 | 6 | 93 | L | 52.00 | |
| 16 | Christian Scott | NYM | @ ATL | 3-5 L | 4.0 | 2 | 3 | 3 | 4 | 7 | 82 | L | 49.00 |
| 17 | Gavin Williams | CLE | vs CHW | 4-3 W | 4.2 | 5 | 3 | 3 | 2 | 6 | 79 | ND | 46.00 |
| 18 | Mike Paredes | MIN | @ NYY | 2-5 L | 4.0 | 4 | 3 | 3 | 2 | 2 | 81 | L | 42.00 |
| 19 | Kyle Harrison | MIL | @ ARI | 7-4 W | 2.2 | 5 | 3 | 3 | 1 | 3 | 72 | ND | 38.00 |
| 20 | Mitch Keller | PIT | @ WSH | 5-9 L | 6.0 | 8 | 5 | 5 | 0 | 1 | 83 | L | 37.00 |
| 21 | Jose Cabrera | ARI | vs MIL | 4-7 L | 3.1 | 6 | 3 | 3 | 3 | 3 | 63 | ND | 36.00 |
| 22 | Reid Detmers | LAA | vs BOS | 2-5 L | 5.0 | 7 | 5 | 5 | 3 | 5 | 104 | L | 35.00 |
| 23 | Tyler Phillips | MIA | @ ATH | 12-5 W | 3.1 | 7 | 5 | 5 | 2 | 2 | 71 | ND | 26.00 |
| 24 | Jack Perkins | ATH | vs MIA | 5-12 L | 3.2 | 7 | 7 | 7 | 4 | 8 | 91 | L | 23.00 |
| 25 | Logan Webb | SF | @ COL | 3-15 L | 3.0 | 11 | 7 | 7 | 2 | 2 | 76 | L | 9.00 |
| 26 | David Peterson | CHC | vs STL | 1-17 L | 3.2 | 9 | 10 | 10 | 3 | 3 | 91 | L | 3.00 |