| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Andrew Luck |
1. Andrew Luck, QB | IND | W 45-44 vs. KC | 29 | 45 | 443 | 4 | 3 | 1 | 0 | 98.7 |
| 2. Alex Smith, QB | KC | L 45-44 at IND | 30 | 46 | 378 | 4 | 0 | 2 | 1 | 119.7 | |
| 4. Drew Brees, QB | NO | W 26-24 at PHI | 20 | 30 | 250 | 1 | 2 | 2 | 0 | 75.7 | |
| 5. Colin Kaepernick, QB | SF | W 23-20 at GB | 16 | 30 | 227 | 1 | 1 | 3 | 0 | 75.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Colin Kaepernick |
1. Colin Kaepernick, QB | SF | W 23-20 at GB | 7 | 98 | 14.0 | 0 | 42 | 0 | |
| 2. Mark Ingram II, RB | NO | W 26-24 at PHI | 18 | 97 | 5.4 | 1 | 18 | 0 | ||
| 3. Eddie Lacy, RB | GB | L 23-20 vs. SF | 21 | 81 | 3.9 | 0 | 8 | 0 | ||
| 4. Ronnie Brown, RB | LAC | W 27-10 at CIN | 8 | 77 | 9.6 | 1 | 58 | 0 | ||
| 5. LeSean McCoy, RB | PHI | L 26-24 vs. NO | 21 | 77 | 3.7 | 1 | 11 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
| 2. Dwayne Bowe, WR | KC | L 45-44 at IND | 8 | 150 | 18.8 | 1 | 63 | 0 | ||
| 3. Marvin Jones Jr., WR | CIN | L 27-10 vs. LAC | 8 | 130 | 16.3 | 0 | 49 | 0 | ||
| 4. Michael Crabtree, WR | SF | W 23-20 at GB | 8 | 125 | 15.6 | 0 | 31 | 0 | ||
| 5. Donnie Avery, WR | KC | L 45-44 at IND | 1 | 79 | 79.0 | 1 | 79 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Rey Maualuga |
1. Rey Maualuga, LB | CIN | L 27-10 vs. LAC | 12 | 3 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Donald Butler, LB | LAC | W 27-10 at CIN | 9 | 3 | 12 | 0.0 | 1 | 0 | 0 | |
| 3. NaVorro Bowman, LB | SF | W 23-20 at GB | 10 | 0 | 10 | 0.0 | 1 | 0 | 0 | |
| 4. DeMeco Ryans, LB | PHI | L 26-24 vs. NO | 8 | 2 | 10 | 0.0 | 0 | 1 | 0 | |
| 5. Antoine Bethea, S | IND | W 45-44 vs. KC | 8 | 1 | 9 | 0.0 | 0 | 0 | 0 | |