| MLB - Pitching - ESPN Player Rating | ||||||||||||||
| RK | PLAYER | TEAM | IP | W | L | SV | BS | K | BB | HBP | BAA | HR | ERA | RAT |
| 1 | Jacob Misiorowski | MIL | 127.0 | 11 | 5 | 0 | 0 | 195 | 29 | 9 | .145 | 11 | 1.63 | 63.7 |
| 2 | Cristopher Sanchez | PHI | 144.0 | 14 | 4 | 0 | 0 | 168 | 33 | 4 | .250 | 12 | 2.61 | 62.0 |
| 3 | Cam Schlittler | NYY | 139.0 | 10 | 6 | 0 | 0 | 171 | 31 | 6 | .199 | 13 | 2.26 | 61.1 |
| 4 | Mason Miller | SD | 47.0 | 4 | 1 | 28 | 1 | 88 | 16 | 1 | .137 | 0 | 0.76 | 55.2 |
| 5 | Chris Sale | ATL | 117.0 | 12 | 6 | 0 | 0 | 143 | 26 | 10 | .215 | 8 | 2.08 | 52.5 |
| 6 | Chase Burns | CIN | 118.0 | 13 | 1 | 0 | 0 | 137 | 43 | 1 | .202 | 13 | 2.35 | 51.4 |
| 7 | Yoshinobu Yamamoto | LAD | 133.0 | 11 | 7 | 0 | 0 | 121 | 29 | 3 | .187 | 15 | 2.76 | 48.8 |
| 8 | Eduardo Rodriguez | ARI | 130.0 | 10 | 3 | 0 | 0 | 88 | 45 | 0 | .233 | 13 | 2.48 | 45.5 |
| 9 | Dylan Cease | TOR | 119.0 | 7 | 5 | 0 | 0 | 174 | 51 | 3 | .184 | 7 | 2.41 | 44.1 |
| 10 | Zack Wheeler | PHI | 105.0 | 10 | 2 | 0 | 0 | 126 | 23 | 2 | .194 | 13 | 2.49 | 44.0 |
| 11 | Bryan Baker | TB | 43.0 | 1 | 0 | 31 | 3 | 46 | 15 | 1 | .147 | 2 | 1.45 | 43.4 |
| 12 | Parker Messick | CLE | 129.0 | 8 | 6 | 0 | 0 | 128 | 37 | 1 | .212 | 11 | 2.57 | 42.9 |
| 13 | Drew Rasmussen | TB | 117.0 | 10 | 5 | 0 | 0 | 122 | 20 | 6 | .205 | 12 | 2.91 | 41.3 |
| 14 | Foster Griffin | CLE | 129.0 | 12 | 3 | 0 | 0 | 116 | 30 | 8 | .226 | 19 | 3.06 | 41.0 |
| 15 | Nick Martinez | TB | 123.0 | 10 | 3 | 0 | 0 | 69 | 20 | 3 | .247 | 15 | 2.77 | 40.5 |
| 16 | Jacob Latz | TEX | 50.0 | 2 | 1 | 21 | 2 | 51 | 11 | 0 | .130 | 3 | 1.80 | 40.2 |
| 17 | Max Meyer | MIA | 111.0 | 9 | 1 | 0 | 0 | 121 | 41 | 7 | .207 | 11 | 2.68 | 39.6 |
| 18 | Louis Varland | TOR | 56.0 | 3 | 4 | 24 | 0 | 73 | 16 | 0 | .205 | 1 | 1.11 | 38.7 |
| 19 | Gavin Williams | CLE | 139.0 | 11 | 6 | 0 | 0 | 178 | 39 | 3 | .209 | 21 | 3.56 | 36.0 |
| 20 | Sonny Gray | BOS | 113.0 | 13 | 2 | 0 | 0 | 98 | 30 | 3 | .242 | 12 | 2.93 | 35.1 |
| 21 | Cade Smith | CLE | 51.0 | 3 | 1 | 30 | 4 | 71 | 16 | 1 | .212 | 4 | 2.45 | 31.8 |
| 22 | Robbie Ray | SF | 122.0 | 10 | 6 | 0 | 0 | 107 | 57 | 1 | .226 | 15 | 3.08 | 30.8 |
| 23 | Jhoan Duran | PHI | 37.0 | 1 | 4 | 25 | 2 | 55 | 6 | 3 | .216 | 1 | 1.93 | 30.6 |
| 24 | Sean Burke | CHW | 124.0 | 7 | 5 | 0 | 0 | 140 | 37 | 8 | .220 | 13 | 3.04 | 29.0 |
| 25 | Nolan McLean | NYM | 125.0 | 7 | 7 | 0 | 0 | 148 | 45 | 13 | .209 | 13 | 3.29 | 28.8 |
| 26 | Justin Wrobleski | LAD | 117.0 | 11 | 3 | 0 | 0 | 91 | 24 | 4 | .228 | 16 | 3.31 | 28.7 |
| 27 | Tarik Skubal | LAD | 96.0 | 7 | 5 | 0 | 0 | 116 | 14 | 4 | .210 | 10 | 2.79 | 27.9 |
| 28 | Walbert Urena | LAA | 99.0 | 7 | 7 | 0 | 0 | 95 | 52 | 8 | .199 | 6 | 2.54 | 27.6 |
| 29 | Dylan Lee | ATL | 51.0 | 5 | 0 | 0 | 1 | 62 | 9 | 0 | .159 | 3 | 2.12 | 27.3 |
| 30 | Casey Mize | DET | 86.0 | 4 | 6 | 0 | 0 | 85 | 19 | 1 | .213 | 5 | 2.70 | 27.0 |
| 31 | Peter Lambert | HOU | 108.0 | 8 | 5 | 0 | 0 | 108 | 41 | 8 | .206 | 11 | 3.06 | 26.9 |
| 32 | Shane McClanahan | TB | 99.0 | 9 | 6 | 0 | 0 | 91 | 35 | 4 | .207 | 7 | 3.09 | 26.9 |
| 33 | Jose Soriano | TOR | 123.0 | 9 | 6 | 0 | 0 | 127 | 57 | 4 | .217 | 12 | 3.29 | 26.7 |
| 34 | Keider Montero | DET | 116.0 | 8 | 6 | 1 | 0 | 81 | 25 | 5 | .212 | 11 | 3.17 | 26.6 |
| 35 | Logan Gilbert | SEA | 132.0 | 8 | 6 | 0 | 0 | 139 | 28 | 5 | .213 | 17 | 3.46 | 26.4 |
| 36 | Sandy Alcantara | MIA | 156.0 | 12 | 6 | 0 | 0 | 120 | 41 | 7 | .246 | 17 | 3.68 | 26.3 |
| 37 | Aroldis Chapman | BOS | 37.0 | 2 | 3 | 27 | 2 | 50 | 17 | 1 | .201 | 1 | 1.67 | 26.1 |
| 38 | Michael Soroka | ARI | 82.0 | 8 | 3 | 0 | 0 | 79 | 17 | 5 | .233 | 6 | 3.07 | 24.6 |
| 39 | Jesus Luzardo | PHI | 128.0 | 9 | 5 | 0 | 0 | 157 | 41 | 9 | .232 | 12 | 3.57 | 24.4 |
| 40 | Raisel Iglesias | ATL | 40.0 | 0 | 2 | 24 | 2 | 44 | 10 | 0 | .216 | 4 | 2.25 | 22.8 |
| 41 | Tanner Scott | LAD | 45.0 | 1 | 3 | 16 | 2 | 59 | 8 | 1 | .198 | 4 | 2.38 | 21.9 |
| 42 | Kyle Harrison | MIL | 83.0 | 8 | 2 | 0 | 0 | 101 | 20 | 4 | .221 | 10 | 3.01 | 21.9 |
| 43 | Braxton Ashcraft | PIT | 127.0 | 11 | 4 | 0 | 0 | 140 | 31 | 7 | .243 | 17 | 3.96 | 21.8 |
| 44 | Paul Sewald | ARI | 37.0 | 2 | 5 | 24 | 3 | 43 | 9 | 1 | .234 | 12 | 6.45 | 21.3 |
| 45 | Ranger Suarez | BOS | 100.0 | 4 | 3 | 0 | 0 | 105 | 28 | 2 | .234 | 5 | 3.15 | 21.0 |
| 46 | Trevor Megill | MIL | 41.0 | 2 | 2 | 18 | 2 | 50 | 11 | 1 | .187 | 0 | 2.83 | 20.7 |
| 47 | Steven Okert | HOU | 55.0 | 5 | 1 | 0 | 1 | 57 | 12 | 3 | .187 | 6 | 2.28 | 20.3 |
| 48 | Colin Holderman | CLE | 43.0 | 6 | 2 | 1 | 0 | 42 | 15 | 4 | .147 | 1 | 1.65 | 20.3 |
| 49 | Luke Weaver | PIT | 44.0 | 2 | 1 | 1 | 2 | 45 | 11 | 2 | .162 | 3 | 1.84 | 20.1 |
| 50 | Kevin Kelly | TB | 51.0 | 5 | 3 | 4 | 2 | 42 | 8 | 3 | .192 | 4 | 2.12 | 19.5 |