| NL - Pitching - ESPN Player Rating | ||||||||||||||
| RK | PLAYER | TEAM | IP | W | L | SV | BS | K | BB | HBP | BAA | HR | ERA | RAT |
| 1 | Jacob Misiorowski | MIL | 139.0 | 12 | 5 | 0 | 0 | 210 | 31 | 9 | .151 | 13 | 1.75 | 64.2 |
| 2 | Cristopher Sanchez | PHI | 161.0 | 16 | 4 | 0 | 0 | 187 | 38 | 5 | .253 | 13 | 2.51 | 63.2 |
| 3 | Mason Miller | SD | 52.0 | 4 | 1 | 31 | 1 | 95 | 19 | 2 | .136 | 0 | 0.86 | 54.0 |
| 4 | Yoshinobu Yamamoto | LAD | 145.0 | 12 | 7 | 0 | 0 | 136 | 34 | 4 | .186 | 15 | 2.60 | 52.3 |
| 5 | Chris Sale | ATL | 129.0 | 12 | 8 | 0 | 0 | 160 | 28 | 10 | .216 | 8 | 2.16 | 50.0 |
| 6 | Chase Burns | CIN | 136.0 | 14 | 2 | 0 | 0 | 159 | 48 | 1 | .208 | 13 | 2.51 | 49.9 |
| 7 | Eduardo Rodriguez | ARI | 149.0 | 12 | 4 | 0 | 0 | 106 | 47 | 0 | .238 | 14 | 2.71 | 46.4 |
| 8 | Jesus Luzardo | PHI | 150.0 | 11 | 5 | 0 | 0 | 185 | 46 | 9 | .227 | 12 | 3.23 | 44.6 |
| 9 | Max Meyer | MIA | 111.0 | 9 | 1 | 0 | 0 | 121 | 41 | 7 | .207 | 11 | 2.68 | 40.5 |
| 10 | Cade Cavalli | WSH | 142.0 | 11 | 5 | 0 | 0 | 162 | 42 | 12 | .244 | 15 | 3.22 | 38.3 |
| 11 | Zack Wheeler | PHI | 120.0 | 10 | 4 | 0 | 0 | 144 | 33 | 3 | .202 | 15 | 2.92 | 37.4 |
| 12 | Sandy Alcantara | MIA | 176.0 | 13 | 8 | 0 | 0 | 131 | 47 | 7 | .240 | 18 | 3.46 | 35.4 |
| 13 | Jhoan Duran | PHI | 45.0 | 1 | 4 | 28 | 2 | 63 | 8 | 3 | .229 | 1 | 1.79 | 34.8 |
| 14 | Nolan McLean | NYM | 142.0 | 9 | 8 | 0 | 0 | 162 | 54 | 14 | .213 | 15 | 3.34 | 28.9 |
| 15 | Robbie Ray | SD | 137.0 | 11 | 7 | 0 | 0 | 117 | 68 | 1 | .226 | 18 | 3.20 | 28.7 |
| 16 | Kyle Harrison | MIL | 98.0 | 10 | 3 | 0 | 0 | 122 | 26 | 4 | .223 | 13 | 2.84 | 28.5 |
| 17 | Trevor Megill | MIL | 48.0 | 2 | 2 | 22 | 2 | 54 | 12 | 1 | .165 | 0 | 2.44 | 27.3 |
| 18 | Dylan Lee | ATL | 58.0 | 5 | 0 | 0 | 1 | 72 | 14 | 0 | .151 | 3 | 2.02 | 27.3 |
| 19 | Tarik Skubal | LAD | 113.0 | 7 | 7 | 0 | 0 | 135 | 20 | 5 | .213 | 12 | 2.85 | 27.3 |
| 20 | Tanner Scott | LAD | 51.0 | 1 | 3 | 18 | 2 | 63 | 11 | 1 | .197 | 4 | 2.28 | 24.9 |
| 21 | Braxton Ashcraft | PIT | 149.0 | 13 | 5 | 0 | 0 | 159 | 33 | 7 | .231 | 21 | 3.68 | 24.7 |
| 22 | Michael Soroka | ARI | 92.0 | 8 | 3 | 0 | 0 | 88 | 21 | 5 | .233 | 6 | 2.93 | 23.1 |
| 23 | Riley O'Brien | STL | 52.0 | 3 | 4 | 33 | 5 | 53 | 22 | 10 | .197 | 2 | 2.94 | 23.1 |
| 24 | Andre Pallante | STL | 136.0 | 12 | 6 | 0 | 0 | 97 | 41 | 6 | .249 | 10 | 3.57 | 22.9 |
| 25 | Kyle Leahy | STL | 122.0 | 10 | 4 | 0 | 0 | 111 | 35 | 5 | .265 | 12 | 3.24 | 20.0 |
| 26 | Michael King | SD | 149.0 | 8 | 9 | 0 | 0 | 128 | 58 | 9 | .217 | 18 | 3.38 | 19.8 |
| 27 | Logan Webb | SF | 139.0 | 8 | 7 | 0 | 0 | 110 | 32 | 6 | .224 | 9 | 3.50 | 19.1 |
| 28 | Ben Brown | CHC | 68.0 | 4 | 2 | 1 | 1 | 65 | 19 | 2 | .186 | 2 | 1.85 | 17.4 |
| 29 | Eury Perez | MIA | 122.0 | 6 | 9 | 0 | 0 | 133 | 49 | 8 | .200 | 13 | 3.23 | 17.4 |
| 30 | Luke Weaver | PIT | 48.0 | 2 | 1 | 1 | 2 | 49 | 12 | 2 | .175 | 3 | 2.25 | 16.2 |
| 31 | Casey Mize | SD | 102.0 | 5 | 7 | 0 | 0 | 95 | 25 | 1 | .224 | 7 | 3.18 | 15.6 |
| 32 | Yuki Matsui | SD | 48.0 | 3 | 1 | 0 | 0 | 50 | 28 | 2 | .172 | 6 | 2.22 | 14.4 |
| 33 | Raisel Iglesias | ATL | 46.0 | 1 | 2 | 26 | 3 | 51 | 14 | 1 | .233 | 5 | 3.09 | 13.2 |
| 34 | Abner Uribe | MIL | 48.0 | 4 | 2 | 6 | 2 | 48 | 18 | 1 | .188 | 3 | 2.05 | 12.9 |
| 35 | Justin Wrobleski | LAD | 126.0 | 11 | 5 | 0 | 0 | 100 | 28 | 5 | .231 | 19 | 3.56 | 12.6 |
| 36 | Tomoyuki Sugano | COL | 118.0 | 12 | 6 | 0 | 0 | 69 | 27 | 2 | .266 | 26 | 4.70 | 11.6 |
| 37 | DL Hall | MIL | 40.0 | 2 | 0 | 0 | 1 | 41 | 28 | 1 | .152 | 3 | 2.43 | 11.4 |
| 38 | Martin Perez | ATL | 111.0 | 8 | 7 | 0 | 0 | 83 | 45 | 2 | .218 | 11 | 3.15 | 10.7 |
| 39 | Alex Vesia | LAD | 44.0 | 1 | 1 | 3 | 2 | 58 | 30 | 0 | .157 | 3 | 3.25 | 10.5 |
| 40 | Dylan Dodd | ATL | 39.0 | 3 | 1 | 1 | 0 | 42 | 12 | 2 | .165 | 4 | 2.27 | 10.2 |
| 41 | Adrian Morejon | SD | 68.0 | 9 | 2 | 2 | 5 | 83 | 19 | 4 | .216 | 4 | 2.78 | 9.9 |
| 42 | Paul Skenes | PIT | 139.0 | 9 | 11 | 0 | 0 | 171 | 41 | 9 | .229 | 14 | 3.95 | 9.0 |
| 43 | Brandon Pfaadt | ARI | 98.0 | 7 | 1 | 0 | 0 | 69 | 24 | 4 | .237 | 11 | 3.39 | 9.0 |
| 44 | Edgardo Henriquez | LAD | 50.0 | 4 | 1 | 1 | 1 | 54 | 23 | 5 | .174 | 1 | 3.06 | 8.4 |
| 45 | Didier Fuentes | ATL | 55.0 | 5 | 1 | 2 | 5 | 73 | 15 | 2 | .220 | 4 | 2.60 | 8.4 |
| 46 | Juan Morillo | ARI | 50.0 | 3 | 4 | 1 | 4 | 59 | 18 | 2 | .196 | 2 | 2.32 | 8.1 |
| 47 | Bradgley Rodriguez | SD | 56.0 | 3 | 2 | 1 | 4 | 60 | 17 | 0 | .204 | 3 | 2.08 | 8.1 |
| 48 | Jacob Webb | CHC | 56.0 | 6 | 2 | 9 | 4 | 63 | 20 | 0 | .219 | 6 | 2.25 | 7.5 |
| 49 | Mason Montgomery | PIT | 50.0 | 5 | 3 | 5 | 2 | 82 | 21 | 0 | .191 | 5 | 3.40 | 7.5 |
| 50 | Michael McGreevy | STL | 137.0 | 5 | 9 | 0 | 0 | 95 | 36 | 0 | .251 | 18 | 3.54 | 7.2 |