| February | |||||
| DATE | RESULT | WIN | LOSS | ||
| February 21, 1:05 PM ET | Boston 7, at Minnesota 2 | -- | -- | ||
| February 22, 3:10 PM ET | LA Dodgers 5, at San Diego 1 | -- | -- | ||
| February 24, 1:07 PM ET | NY Yankees 8, at Toronto 7 | -- | -- | ||
| February 24, 3:05 PM ET | at LA Dodgers 11, Cleveland 3 | -- | -- | ||
| February 25, 1:05 PM ET | at Philadelphia 5, Detroit 3 | -- | -- | ||
| February 25, 3:10 PM ET | at San Diego 7, LA Angels 3 | -- | -- | ||
| February 27, 1:05 PM ET | at Philadelphia 10, Miami 2 | -- | -- | ||
| February 27, 3:05 PM ET | at San Francisco 12, LA Dodgers 4 | -- | -- | ||
| February 28, 1:05 PM ET | at Boston 13, Minnesota 8 | -- | -- | ||
| March | |||||
| DATE | RESULT | WIN | LOSS | ||
| March 1, 1:05 PM ET | at Minnesota 2, Atlanta 2 | -- | -- | ||
| March 2, 1:00 PM ET | Atlanta 5, at Detroit 2 | -- | -- | ||
| March 2, 3:10 PM ET | Athletics 7, at San Diego 2 | -- | -- | ||
| March 4, 1:05 PM ET | NY Yankees 4, at Boston 0 | -- | -- | ||
| March 5, 1:05 PM ET | at Philadelphia 6, Boston 2 | -- | -- | ||
| March 5, 3:00 PM ET | at Cincinnati 14, LA Dodgers 13 | -- | -- | ||
| March 6, 1:05 PM ET | St. Louis 10, at Baltimore 2 | -- | -- | ||
| March 6, 3:05 PM ET | at Cleveland 5, LA Angels 3 | -- | -- | ||
| March 6, 8:10 PM ET | at San Diego 3, Chicago Cubs 0 | -- | -- | ||
| March 7, 1:05 PM ET | Pittsburgh 5, at Detroit 3 | -- | -- | ||
| March 7, 3:05 PM ET | at San Francisco 7, Texas 5 | -- | -- | ||
| March 7, 8:05 PM ET | Colorado 6, at LA Dodgers 4 | -- | -- | ||
| March 8, 4:05 PM ET | San Francisco 9, at Chicago Cubs 5 | -- | -- | ||
| March 9, 1:05 PM ET | at St. Louis 7, Baltimore 2 | -- | -- | ||
| March 9, 4:10 PM ET | LA Dodgers 4, at Milwaukee 3 | -- | -- | ||
| March 9, 6:10 PM ET | at NY Mets 9, Miami 0 | -- | -- | ||
| March 10, 1:07 PM ET | at Toronto 7, Atlanta 0 | -- | -- | ||
| March 11, 6:35 PM ET | at NY Yankees 8, Toronto 1 | -- | -- | ||
| March 12, 1:05 PM ET | at Minnesota 8, Boston 5 | -- | -- | ||
| March 13, 4:05 PM ET | San Diego 13, at Athletics 9 | -- | -- | ||
| March 14, 1:07 PM ET | Detroit 6, at Toronto 1 | -- | -- | ||
| March 14, 4:05 PM ET | Arizona 8, at San Francisco 7 | -- | -- | ||
| March 14, 6:05 PM ET | at Houston 8, NY Mets 2 | -- | -- | ||
| March 15, 1:05 PM ET | Atlanta 1, at Philadelphia 0 | -- | -- | ||
| March 16, 4:05 PM ET | Milwaukee 24, at LA Dodgers 9 | -- | -- | ||
| March 16, 8:05 PM ET | at Texas 3, Chicago Sox 2 | -- | -- | ||
| March 18, 4:05 PM ET | at LA Dodgers 5, San Francisco 1 | -- | -- | ||
| March 20, 1:10 PM ET | St. Louis 4, at NY Mets 3 | -- | -- | ||
| March 22, 9:07 PM ET | LA Dodgers 13, at LA Angels 5 | -- | -- | ||
| March 23, 1:05 PM ET | Baltimore 2, at Washington 0 | -- | -- | ||
| March 23, 8:05 PM ET | at Texas 3, Kansas City 2 | -- | -- | ||
| March 24, 1:05 PM ET | at Minnesota 15, Boston 6 | -- | -- | ||
| March 26, 1:15 PM ET | at NY Mets 11, Pittsburgh 7 | Peralta (1-0) | Skenes (0-1) | ||
| March 26, 4:10 PM ET | Detroit 8, at San Diego 2 | Skubal (1-0) | Pivetta (0-1) | ||
| March 26, 8:30 PM ET | at LA Dodgers 8, Arizona 2 | Yamamoto (1-0) | Gallen (0-1) | ||
| March 27, 7:07 PM ET | at Toronto 3, Athletics 2 | Hoffman (1-0) | Sterner (0-1) | ||
| March 27, 10:10 PM ET | at LA Dodgers 5, Arizona 4 | Henriquez (1-0) | Ginkel (0-1) | ||
| March 28, 4:05 PM ET | Minnesota 4, at Baltimore 1 | Banda (1-0) | Bradish (0-1) | ||
| March 28, 7:15 PM ET | at Atlanta 6, Kansas City 2 | Bido (1-0) | Estevez (0-1) | ||
| March 28, 7:15 PM ET | NY Yankees 3, at San Francisco 1 | Bird (1-0) | Mahle (0-1) | ||
| March 28, 9:40 PM ET | Cleveland 6, at Seattle 5 | Smith (1-0) | Munoz (0-1) | ||
| March 29, 1:35 PM ET | Kansas City 4, at Atlanta 1 | Lugo (1-0) | Holmes (0-1) | ||
| March 30, 6:40 PM ET | at Cincinnati 2, Pittsburgh 0 | Burns (1-0) | Ashcraft (0-1) | ||
| March 30, 9:40 PM ET | San Francisco 3, at San Diego 2 | Roupp (1-0) | Buehler (0-1) | ||
| March 31, 9:40 PM ET | NY Yankees 5, at Seattle 0 | Fried (2-0) | Gilbert (0-1) | ||
| April | |||||
| DATE | RESULT | WIN | LOSS | ||
| April 2, 9:45 PM ET | at San Francisco 7, NY Mets 2 | Ray (1-1) | Peterson (0-1) | ||
| April 4, 2:10 PM ET | Milwaukee 5, at Kansas City 2 | Patrick (1-0) | Avila (0-1) | ||
| April 4, 7:15 PM ET | Chicago Cubs @ Cleveland | Postponed | |||
| April 4, 7:15 PM ET | at Arizona 2, Atlanta 1 | Soroka (2-0) | Elder (1-1) | ||
| April 6, 7:07 PM ET | LA Dodgers 14, at Toronto 2 | Wrobleski (1-0) | Scherzer (1-1) | ||
| April 7, 7:07 PM ET | LA Dodgers 4, at Toronto 1 | Yamamoto (2-1) | Gausman (0-1) | ||
| April 8, 7:40 PM ET | at Minnesota 8, Detroit 6 | Ober (1-0) | Valdez (1-1) | ||
| April 9, 7:10 PM ET | Arizona 7, at NY Mets 1 | Rodriguez (1-0) | McLean (1-1) | ||
| April 11, 1:05 PM ET | at Philadelphia 4, Arizona 3 | Walker (1-2) | Pfaadt (0-1) | ||
| April 11, 7:15 PM ET | at Baltimore 6, San Francisco 2 | Wolfram (1-0) | Webb (1-2) | ||
| April 11, 7:15 PM ET | Boston 7, at St. Louis 1 | Suarez (1-1) | Leahy (1-2) | ||
| April 12, 7:20 PM ET | at Atlanta 13, Cleveland 1 | Sale (3-1) | Bibee (0-2) | ||
| April 13, 6:40 PM ET | at Philadelphia 13, Chicago Cubs 7 | Sanchez (2-1) | Assad (1-1) | ||
| April 14, 6:40 PM ET | Chicago Cubs 10, at Philadelphia 4 | Rea (2-0) | Mayza (0-1) | ||
| April 15, 10:00 PM ET | at LA Dodgers 8, NY Mets 2 | Ohtani (2-0) | Holmes (2-2) | ||
| April 16, 8:40 PM ET | at San Diego 5, Seattle 2 | Buehler (1-1) | Castillo (0-1) | ||
| April 18, 7:15 PM ET | Atlanta 3, at Philadelphia 1 | Sale (4-1) | Sanchez (2-2) | ||
| April 18, 7:15 PM ET | at Seattle 7, Texas 3 | Kirby (3-2) | Eovaldi (2-3) | ||
| April 20, 7:40 PM ET | Baltimore 7, at Kansas City 5 | Nunez (1-0) | Lange (0-2) | ||
| April 21, 6:45 PM ET | NY Yankees 4, at Boston 0 | Gil (1-1) | Early (1-1) | ||
| April 22, 6:45 PM ET | NY Yankees 4, at Boston 1 | Fried (3-1) | Suarez (1-2) | ||
| April 23, 6:10 PM ET | NY Yankees 4, at Boston 2 | Schlittler (3-1) | Coulombe (0-1) | ||
| April 25, 3:07 PM ET | at Toronto 5, Cleveland 3 | Gausman (2-1) | Cantillo (1-1) | ||
| April 25, 7:15 PM ET | at Cincinnati 9, Detroit 2 | Singer (2-1) | Flaherty (0-2) | ||
| April 25, 7:15 PM ET | at LA Dodgers 12, Chicago Cubs 4 | Sasaki (1-2) | Rea (3-1) | ||
| April 27, 6:10 PM ET | Tampa Bay 3, at Cleveland 2 | Matz (4-1) | Gaddis (0-1) | ||
| April 27, 7:40 PM ET | at Minnesota 11, Seattle 4 | Prielipp (1-0) | Castillo (0-2) | ||
| April 28, 7:15 PM ET | at Atlanta 5, Detroit 2 | Perez (2-1) | Mize (2-2) | ||
| April 29, 6:10 PM ET | San Francisco @ Philadelphia | Postponed | |||
| April 30, 5:35 PM ET | at Philadelphia 6, San Francisco 5 | Shugart (2-0) | Gage (2-1) | ||
| May | |||||
| DATE | RESULT | WIN | LOSS | ||
| May 2, 4:05 PM ET | at Pittsburgh 17, Cincinnati 7 | Mlodzinski (2-2) | Lowder (3-2) | ||
| May 2, 7:15 PM ET | at Detroit 5, Texas 1 | Montero (2-2) | Rocker (1-3) | ||
| May 2, 7:15 PM ET | at St. Louis 3, LA Dodgers 2 | McGreevy (2-2) | Sasaki (1-3) | ||
| DATE | GAME | NETWORK | PITCHERS | ||
| May 4, 7:45 PM ET | Milwaukee @ St. Louis | FS1 | Patrick vs Leahy | ||
| May 5, 8:10 PM ET | LA Dodgers @ Houston | TBS | Ohtani vs Lambert | ||
| May 6, 7:05 PM ET | Texas @ NY Yankees | MLB Net | Eovaldi vs Warren | ||
| May 7, 7:00 PM ET | Tampa Bay @ Boston |  | Scholtens vs Early | ||
| May 7, 10:00 PM ET | St. Louis @ San Diego | | McGreevy vs King | ||
| May 9, 4:10 PM ET | Houston @ Cincinnati | FS1 | Arrighetti vs Undecided | ||
| May 9, 7:15 PM ET | NY Mets @ Arizona | FOX | Holmes vs Kelly | ||
| May 9, 7:15 PM ET | St. Louis @ San Diego | FOX | Leahy vs Vasquez | ||
| May 11, 8:10 PM ET | Seattle @ Houston | FS1 | Kirby vs Lambert | ||
| May 12, 7:15 PM ET | Chicago Cubs @ Atlanta | TBS | Rea vs Elder | ||
| May 14, 10:10 PM ET | San Francisco @ LA Dodgers | MLB Net | Roupp vs Sheehan | ||
| May 16, 4:05 PM ET | Baltimore @ Washington | FS1 | |||
| May 16, 7:15 PM ET | NY Yankees @ NY Mets | FOX | |||
| May 16, 7:15 PM ET | San Diego @ Seattle | FOX | |||
| May 18, 6:40 PM ET | Cleveland @ Detroit | FS1 | |||
| May 19, 7:05 PM ET | Toronto @ NY Yankees | TBS | |||
| May 20, 7:05 PM ET | Toronto @ NY Yankees | MLB Net | |||
| May 21, 7:05 PM ET | Toronto @ NY Yankees | MLB Net | |||
| May 23, 4:10 PM ET | Seattle @ Kansas City | FS1 | |||
| May 23, 7:15 PM ET | St. Louis @ Cincinnati | FOX | |||
| May 23, 7:15 PM ET | LA Dodgers @ Milwaukee | FOX | |||
| May 25, 3:40 PM ET | NY Yankees @ Kansas City | | |||
| May 26, 6:45 PM ET | Atlanta @ Boston | TBS | |||
| May 27, 6:35 PM ET | Tampa Bay @ Baltimore | FS1 | |||
| May 30, 4:05 PM ET | Kansas City @ Texas | FS1 | |||
| May 30, 7:15 PM ET | Atlanta @ Cincinnati | FOX | |||
| May 30, 7:15 PM ET | Chicago Cubs @ St. Louis | FOX | |||
| May 31, 7:20 PM ET | Chicago Cubs @ St. Louis | NBC | |||
| June | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| June 1, 7:40 PM ET | San Francisco @ Milwaukee | FS1 | |||
| June 2, 6:40 PM ET | San Diego @ Philadelphia | TBS | |||
| June 3, 9:40 PM ET | LA Dodgers @ Arizona | MLB Net | |||
| June 4, 8:10 PM ET | Pittsburgh @ Houston | FS1 | |||
| June 6, 7:35 PM ET | Boston @ NY Yankees | FOX | |||
| June 6, 7:35 PM ET | Cleveland @ Texas | FOX | |||
| June 7, 8:20 PM ET | San Francisco @ Chicago Cubs | NBC | |||
| June 8, 6:40 PM ET | NY Yankees @ Cleveland | FS1 | |||
| June 9, 6:40 PM ET | NY Yankees @ Cleveland | TBS | |||
| June 13, 7:15 PM ET | Houston @ Kansas City | FOX | |||
| June 13, 7:15 PM ET | Philadelphia @ Milwaukee | FOX | |||
| June 14, 7:20 PM ET | Texas @ Boston | NBC | |||
| June 16, 8:10 PM ET | Detroit @ Houston | TBS | |||
| June 18, 6:40 PM ET | NY Mets @ Philadelphia | MLB Net | |||
| June 20, 7:15 PM ET | NY Mets @ Philadelphia | FOX | |||
| June 20, 7:15 PM ET | Cleveland @ Houston | FOX | |||
| June 21, 7:20 PM ET | NY Mets @ Philadelphia | NBC | |||
| June 22, 10:00 PM ET | Atlanta @ San Diego | | |||
| June 23, 7:10 PM ET | Chicago Cubs @ NY Mets | TBS | |||
| June 25, 7:10 PM ET | NY Yankees @ Boston | MLB Net | |||
| June 27, 8:40 PM ET | LA Dodgers @ San Diego | MLB Net | |||
| June 28, 7:20 PM ET | NY Yankees @ Boston | NBC | |||
| June 30, 7:05 PM ET | Detroit @ NY Yankees | TBS | |||
| July | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| July 2, 10:10 PM ET | San Diego @ LA Dodgers | MLB Net | |||
| July 4, 8:08 PM ET | NY Mets @ Atlanta | FOX | |||
| July 4, 8:08 PM ET | St. Louis @ Chicago Cubs | FOX | |||
| July 5, 12:30 PM ET | NY Mets @ Atlanta | NBC | |||
| July 5, 7:20 PM ET | San Diego @ LA Dodgers | NBC | |||
| July 6, 9:40 PM ET | Arizona @ San Diego | FS1 | |||
| July 11, 4:10 PM ET | Boston @ NY Mets | FS1 | |||
| July 16, 7:00 PM ET | NY Mets @ Philadelphia | | |||
| July 18, 8:08 PM ET | LA Dodgers @ NY Yankees | FOX | |||
| July 18, 8:08 PM ET | San Francisco @ Seattle | FOX | |||
| July 18, 10:07 PM ET | Detroit @ LA Angels | FS1 | |||
| July 19, 7:20 PM ET | LA Dodgers @ NY Yankees | NBC | |||
| July 25, 4:10 PM ET | San Diego @ Miami | FS1 | |||
| July 25, 7:15 PM ET | LA Dodgers @ NY Mets | FOX | |||
| July 25, 7:15 PM ET | Seattle @ Texas | FOX | |||
| July 26, 7:20 PM ET | NY Yankees @ Philadelphia | NBC | |||
| August | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| August 1, 4:10 PM ET | Minnesota @ Seattle | FS1 | |||
| August 1, 7:15 PM ET | Arizona @ Cleveland | FOX | |||
| August 1, 7:15 PM ET | NY Yankees @ Chicago Cubs | FOX | |||
| August 2, 7:20 PM ET | Boston @ LA Dodgers | NBC | |||
| August 8, 4:10 PM ET | LA Angels @ Miami | FS1 | |||
| August 8, 7:15 PM ET | Baltimore @ Texas | FOX | |||
| August 8, 7:15 PM ET | Detroit @ San Francisco | FOX | |||
| August 8, 7:15 PM ET | Houston @ San Diego | FOX | |||
| August 9, 8:20 PM ET | Houston @ San Diego | NBC | |||
| August 10, 7:45 PM ET | Philadelphia @ St. Louis | FS1 | |||
| August 15, 4:10 PM ET | Washington @ NY Mets | FS1 | |||
| August 15, 7:15 PM ET | Arizona @ Atlanta | FOX | |||
| August 15, 7:15 PM ET | Milwaukee @ LA Dodgers | FOX | |||
| August 16, 7:20 PM ET | Seattle @ Houston | NBC | |||
| August 22, 4:10 PM ET | Washington @ Miami | FS1 | |||
| August 22, 7:15 PM ET | San Francisco @ Boston | FOX | |||
| August 22, 7:15 PM ET | Detroit @ Kansas City | FOX | |||
| August 22, 9:40 PM ET | Chicago Cubs @ Seattle | FOX | |||
| August 23, 3:10 PM ET | San Francisco @ Boston | NBC | |||
| August 23, 7:00 PM ET | Atlanta @ Milwaukee | | |||
| August 24, 6:40 PM ET | Tampa Bay @ Detroit | FS1 | |||
| August 24, 9:45 PM ET | Cincinnati @ San Francisco | FS1 | |||
| August 27, 7:15 PM ET | LA Dodgers @ Atlanta | FS1 | |||
| August 29, 7:15 PM ET | Boston @ NY Yankees | FOX | |||
| August 29, 7:15 PM ET | Texas @ Milwaukee | FOX | |||
| August 30, 3:10 PM ET | Cincinnati @ Chicago Cubs | NBC | |||
| August 30, 7:20 PM ET | Houston @ NY Mets | NBC | |||
| August 31, 7:40 PM ET | Milwaukee @ Chicago Cubs | FS1 | |||
| September | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| September 3, 8:05 PM ET | Tampa Bay @ Texas | FS1 | |||
| September 5, 7:15 PM ET | Boston @ Baltimore | FOX | |||
| September 5, 7:15 PM ET | Detroit @ Cleveland | FOX | |||
| September 5, 7:15 PM ET | Arizona @ Houston | FOX | |||
| September 6, 3:10 PM ET | Atlanta @ Philadelphia | NBC | |||
| September 7, 8:10 PM ET | St. Louis @ San Francisco | NBC | |||
| September 17, 7:15 PM ET | Philadelphia @ NY Mets | FOX | |||
| September 17, 7:15 PM ET | Kansas City @ Houston | FOX | |||
| September 21, 6:35 PM ET | Toronto @ Baltimore | FS1 | |||
| September 24, 7:15 PM ET | Cincinnati @ Atlanta | FS1 | |||
| September 26, 7:15 PM ET | Chicago Cubs @ Boston | FOX | |||