| March | |||||
| DATE | RESULT | WIN | LOSS | ||
| March 2, 1:05 PM ET | at Boston 9, Tampa Bay 3 | -- | -- | ||
| March 3, 3:05 PM ET | at Chicago Cubs 8, Seattle 8 | -- | -- | ||
| March 4, 1:00 PM ET | at NY Mets 8, Washington 4 | -- | -- | ||
| March 5, 3:05 PM ET | LA Dodgers 7, at Kansas City 5 | -- | -- | ||
| April | |||||
| DATE | RESULT | WIN | LOSS | ||
| April 1, 1:05 PM ET | Toronto 3, at NY Yankees 2 | Romano (1-0) | Nelson (0-1) | ||
| April 1, 4:10 PM ET | at Colorado 8, LA Dodgers 5 | Gonzalez (1-0) | Kershaw (0-1) | ||
| April 1, 7:09 PM ET | NY Mets @ Washington | Postponed | |||
| April 1, 10:07 PM ET | Houston 8, at Oakland 1 | Greinke (1-0) | Bassitt (0-1) | ||
| April 4, 1:05 PM ET | at Philadelphia 2, Atlanta 1 | Alvarado (1-0) | Martin (0-1) | ||
| April 4, 8:37 PM ET | at LA Angels 7, Chicago Sox 4 | Iglesias (1-0) | Ruiz (0-1) | ||
| April 5, 1:10 PM ET | Minnesota 15, at Detroit 6 | Shoemaker (1-0) | Urena (0-1) | ||
| April 5, 4:10 PM ET | Kansas City 3, at Cleveland 0 | Duffy (1-0) | Allen (0-1) | ||
| April 5, 7:10 PM ET | at Boston 11, Tampa Bay 2 | Pivetta (1-0) | Wacha (0-1) | ||
| April 5, 10:10 PM ET | Chicago Sox 6, at Seattle 0 | Rodon (1-0) | Sheffield (0-1) | ||
| April 6, 7:05 PM ET | NY Mets 8, at Philadelphia 4 | Stroman (1-0) | Anderson (0-1) | ||
| April 11, 7:08 PM ET | Philadelphia 7, at Atlanta 6 | Alvarado (2-0) | Smith (0-2) | ||
| April 13, 8:00 PM ET | at NY Mets 4, Philadelphia 0 | Stroman (2-0) | Nola (0-1) | ||
| April 13, 9:45 PM ET | at San Francisco 7, Cincinnati 6 | Peralta (2-0) | Perez (1-1) | ||
| April 17, 4:05 PM ET | at Boston 7, Chicago Sox 4 | Ottavino (2-1) | Heuer (1-1) | ||
| April 17, 9:07 PM ET | Minnesota @ LA Angels | Postponed | |||
| April 18, 7:00 PM ET | Atlanta 13, at Chicago Cubs 4 | Wilson (1-0) | Hendricks (0-2) | ||
| April 20, 7:30 PM ET | at Chicago Cubs 3, NY Mets 1 | Arrieta (3-1) | Walker (0-1) | ||
| April 21, 6:30 PM ET | Atlanta 4, at NY Yankees 1 | Anderson (1-0) | Kluber (0-2) | ||
| April 23, 10:10 PM ET | San Diego 6, at LA Dodgers 1 | Darvish (2-1) | Kershaw (3-2) | ||
| April 24, 4:05 PM ET | Washington 7, at NY Mets 1 | Ross (2-1) | Stroman (3-1) | ||
| April 24, 7:10 PM ET | at Chicago Sox 2, Texas 1 | Hendriks (1-0) | King (2-1) | ||
| April 24, 9:10 PM ET | at LA Dodgers 5, San Diego 4 | Bauer (3-0) | Johnson (0-1) | ||
| April 25, 7:00 PM ET | San Diego 8, at LA Dodgers 7 | Hill (1-2) | Cleavinger (0-1) | ||
| April 26, 7:00 PM ET | at Atlanta 8, Chicago Cubs 7 | Morton (2-1) | Workman (0-2) | ||
| April 27, 7:10 PM ET | Boston 2, at NY Mets 1 | Richards (1-2) | Peterson (1-3) | ||
| April 28, 7:20 PM ET | at Atlanta 10, Chicago Cubs 0 | Ynoa (2-1) | Hendricks (1-3) | ||
| April 29, 7:20 PM ET | Chicago Cubs 9, at Atlanta 3 | Alzolay (1-2) | Wilson (1-2) | ||
| May | |||||
| DATE | RESULT | WIN | LOSS | ||
| May 1, 4:05 PM ET | at Chicago Sox 7, Cleveland 3 | Lynn (2-1) | McKenzie (0-1) | ||
| May 2, 7:00 PM ET | NY Mets 8, at Philadelphia 7 | Barnes (1-0) | Kintzler (1-1) | ||
| May 4, 7:00 PM ET | at NY Yankees 7, Houston 3 | Luetge (2-0) | Bielak (1-1) | ||
| May 5, 7:30 PM ET | at Chicago Cubs 6, LA Dodgers 5 | Mills (2-0) | Cleavinger (0-3) | ||
| May 8, 4:05 PM ET | at San Francisco 7, San Diego 1 | Gausman (3-0) | Musgrove (2-4) | ||
| May 8, 7:20 PM ET | at Atlanta 8, Philadelphia 7 | Webb (1-1) | De Los Santos (0-1) | ||
| May 9, 7:00 PM ET | at Atlanta 6, Philadelphia 1 | Ynoa (4-1) | Nola (3-2) | ||
| May 10, 8:00 PM ET | LA Angels 5, at Houston 4 | Suarez (1-0) | Bielak (1-2) | ||
| May 11, 7:00 PM ET | NY Yankees 3, at Tampa Bay 1 | Montgomery (2-1) | Patino (1-1) | ||
| May 15, 4:05 PM ET | at Minnesota 5, Oakland 4 | Colome (2-3) | Diekman (2-1) | ||
| May 15, 8:40 PM ET | at San Diego 13, St. Louis 3 | Diaz (2-0) | Wainwright (2-4) | ||
| May 16, 7:00 PM ET | at San Diego 5, St. Louis 3 | Lamet (1-0) | Kim (1-1) | ||
| DATE | GAME | NETWORK | PITCHERS | ||
| May 17, 7:00 PM ET | NY Mets @ Atlanta |  | Walker vs Fried | ||
| May 18, 8:00 PM ET | NY Yankees @ Texas | | Taillon vs Foltynewicz | ||
| May 21, 7:10 PM ET | Milwaukee @ Cincinnati | FS1 | Houser vs Hoffman | ||
| May 22, 7:15 PM ET | Boston @ Philadelphia | FOX | Eovaldi vs Anderson | ||
| May 22, 7:15 PM ET | Chicago Cubs @ St. Louis | FOX | Alzolay vs Wainwright | ||
| May 22, 7:15 PM ET | LA Dodgers @ San Francisco | FOX | Buehler vs Webb | ||
| May 23, 7:00 PM ET | Chicago Cubs @ St. Louis | | Davies vs Kim | ||
| May 24, 8:00 PM ET | St. Louis @ Chicago Sox | | Gant vs Lynn | ||
| May 25, 8:10 PM ET | LA Dodgers @ Houston | FS1 | Kershaw vs Greinke | ||
| May 26, 7:30 PM ET | LA Dodgers @ Houston | | Bauer vs Garcia | ||
| May 29, 7:15 PM ET | Atlanta @ NY Mets | FOX | |||
| May 29, 7:15 PM ET | Milwaukee @ Washington | FOX | |||
| May 29, 7:15 PM ET | San Francisco @ LA Dodgers | FOX | |||
| May 30, 7:00 PM ET | Atlanta @ NY Mets | | |||
| May 31, 1:00 PM ET | Minnesota @ Baltimore | | |||
| May 31, 4:00 PM ET | Boston @ Houston | | |||
| May 31, 8:00 PM ET | Pittsburgh @ Kansas City | | |||
| June | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| June 1, 6:10 PM ET | Chicago Sox @ Cleveland | FS1 | |||
| June 2, 8:00 PM ET | Boston @ Houston | | |||
| June 5, 7:15 PM ET | Boston @ NY Yankees | FOX | |||
| June 5, 7:15 PM ET | Chicago Cubs @ San Francisco | FOX | |||
| June 5, 7:15 PM ET | LA Dodgers @ Atlanta | FOX | |||
| June 8, 7:10 PM ET | Washington @ Tampa Bay | FS1 | |||
| June 12, 7:15 PM ET | Houston @ Minnesota | FOX | |||
| June 12, 7:15 PM ET | San Francisco @ Washington | FOX | |||
| June 12, 7:15 PM ET | St. Louis @ Chicago Cubs | FOX | |||
| June 19, 7:15 PM ET | Chicago Sox @ Houston | FOX | |||
| June 19, 7:15 PM ET | Cincinnati @ San Diego | FOX | |||
| June 19, 7:15 PM ET | St. Louis @ Atlanta | FOX | |||
| June 19, 10:07 PM ET | Detroit @ LA Angels | FS1 | |||
| June 26, 4:05 PM ET | Kansas City @ Texas | FS1 | |||
| June 26, 7:15 PM ET | Chicago Cubs @ LA Dodgers | FOX | |||
| June 26, 7:15 PM ET | NY Yankees @ Boston | FOX | |||
| July | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| July 3, 4:05 PM ET | San Diego @ Philadelphia | FS1 | |||
| July 3, 7:15 PM ET | Boston @ Oakland | FOX | |||
| July 3, 7:15 PM ET | Houston @ Cleveland | FOX | |||
| July 3, 7:15 PM ET | LA Dodgers @ Washington | FOX | |||
| July 4, 7:00 PM ET | NY Mets @ NY Yankees | | |||
| July 10, 4:05 PM ET | Oakland @ Texas | FS1 | |||
| July 10, 7:15 PM ET | Cincinnati @ Milwaukee | FOX | |||
| July 10, 7:15 PM ET | NY Yankees @ Houston | FOX | |||
| July 10, 7:15 PM ET | St. Louis @ Chicago Cubs | FOX | |||
| July 15, 7:00 PM ET | Boston @ NY Yankees | | |||
| July 17, 4:07 PM ET | Cleveland @ Oakland | FS1 | |||
| July 17, 7:15 PM ET | Boston @ NY Yankees | FOX | |||
| July 17, 7:15 PM ET | Houston @ Chicago Sox | FOX | |||
| July 17, 7:15 PM ET | San Francisco @ St. Louis | FOX | |||
| July 18, 7:00 PM ET | Boston @ NY Yankees | | |||
| July 24, 4:05 PM ET | NY Yankees @ Boston | FS1 | |||
| July 24, 7:10 PM ET | Tampa Bay @ Cleveland | FS1 | |||
| July 31, 4:05 PM ET | Oakland @ LA Angels | FS1 | |||
| July 31, 7:15 PM ET | Minnesota @ St. Louis | FS1 | |||
| August | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| August 7, 4:05 PM ET | NY Mets @ Philadelphia | FS1 | |||
| August 7, 8:40 PM ET | Arizona @ San Diego | FS1 | |||
| August 12, 7:15 PM ET | NY Yankees @ Chicago Sox | FOX | |||
| August 14, 4:05 PM ET | Cincinnati @ Philadelphia | FS1 | |||
| August 21, 1:05 PM ET | Minnesota @ NY Yankees | FS1 | |||
| August 21, 4:05 PM ET | Washington @ Milwaukee | FS1 | |||
| August 22, 7:10 PM ET | LA Angels @ Cleveland | | |||
| August 28, 4:05 PM ET | Boston @ Cleveland | FS1 | |||
| August 28, 9:07 PM ET | San Diego @ LA Angels | FS1 | |||
| August 31, 9:45 PM ET | Milwaukee @ San Francisco | FS1 | |||
| September | |||||
| DATE | GAME | NETWORK | PITCHERS | ||
| September 4, 4:10 PM ET | Minnesota @ Tampa Bay | FS1 | |||
| September 6, 4:00 PM ET | San Francisco @ Colorado | | |||
| September 7, 6:40 PM ET | NY Mets @ Miami | FS1 | |||
| September 11, 7:40 PM ET | NY Yankees @ NY Mets | FOX | |||
| September 12, 8:00 PM ET | NY Yankees @ NY Mets | | |||
| September 14, 7:40 PM ET | Cleveland @ Minnesota | FS1 | |||
| September 21, 10:10 PM ET | San Francisco @ San Diego | FS1 | |||
| September 28, 7:20 PM ET | Philadelphia @ Atlanta | FS1 | |||